Royal Society of Chemistry

SN2 regioselectivity in the esterification of 5- and 7-membered azacycloalkane quaternary salts: a DFT study to reveal the transition state ring conformation prevailing over the ground state ring strain

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00695J, PaperAkihiro Kimura, Susumu Kawauchi, Takuya Yamamoto, Yasuyuki Tezuka
SN2 regioselectivity in 5- and 7-membered azacycloalkanes quaternary salts is directed by the transition state ring conformation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of antineurotoxicity properties of an amyloid-[small beta] peptide targeting ligand containing a triamino acid

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00959B, PaperDmytro Honcharenko, Partha Pratim Bose, Jyotirmoy Maity, Firoz Roshan Kurudenkandy, Alok Juneja, Erik Floistrup, Henrik Biverstal, Jan Johansson, Lennart Nilsson, Andre Fisahn, Roger Stromberg
A new triamino acid enables synthesis of an amyloid-[small beta] peptide (A[small beta]) targeting ligand with additional A[small beta]-ligand interactions that gives protection towards A[small beta]-induced reduction of gamma oscillations in hippocampal slice preparation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Convenient access to readily soluble symmetrical dialkyl-substituted [small alpha]-oligofurans

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00898G, PaperEdward E. Korshin, Gregory M. Leitus, Michael Bendikov
A combination of heteroatom directed lithiation/CuCl2-induced homocoupling, Wittig olefination/Pd-catalyzed transfer hydrogenation followed by Suzuki-Miyaura or Stille cross-coupling enables convenient access to dialkyl-substituted [small alpha]-oligofurans of potential interest for organic electronics.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of methyl 2-cyano-3,12-dioxo-18[small beta]-olean-1,9(11)-dien-30-oate analogues to determine the active groups for inhibiting cell growth and inducing apoptosis in leukemia cells

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00703D, PaperXiaojing Li, Yuetong Wang, Yuan Gao, Lei Li, Xin Guo, Dan Liu, Yongkui Jing, Linxiang Zhao
A series of CDODO-Me-12 analogues were synthesized with improved ability to inhibit cell growth and induce apoptosis in HL-60 cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00882K, PaperSankar K. Guchhait, Vikas Chaudhary
Nucleophilic activation of TMSCN as an isocyanide equivalent by DABCO-THF in the Strecker-Ugi reaction facilitates the synthesis of functional imidazoles which, as building blocks, afford access to C8-N9 annulated purines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalyst-free activation of methylene chloride and alkynes by amines in a three-component coupling reaction to synthesize propargylamines

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00986J, PaperVikas S. Rawat, Thulasiram Bathini, S. Govardan, Bojja Sreedhar
Propargylamines are synthesized via metal-free activation of the C-halogen bond of dihalomethanes and the C-H bond of terminal alkynes in a three-component coupling without catalyst or additional base and under mild reaction conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mutation of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase at Trp-110 affects stereoselectivity of aromatic ketone reduction

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,5905-5910
DOI: 10.1039/C4OB00794H, PaperJay M. Patel, Musa M. Musa, Luis Rodriguez, Dewey A. Sutton, Vladimir V. Popik, Robert S. Phillips
Secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus was mutated at Trp-110, and mutant enzymes with high activity and high stereoselectivity for aromatic ketone reduction were identified.
The content of this RSS Feed (c) The Royal Society of Chemistry

Breaking the dichotomy of reactivity vs. chemoselectivity in catalytic SN1 reactions of alcohols

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,5990-5994
DOI: 10.1039/C4OB01265H, PaperMalik Hellal, Florian C. Falk, Elena Wolf, Marian Dryzhakov, Joseph Moran
B(C6F5)3 possesses a different reactivity/chemoselectivity profile than traditional Lewis and Bronsted acids and is effective at enabling catalytic SN1 reactions of alcohols in the presence of acid sensitive groups without compromising reaction rates, substrate scope or catalyst loadings.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to [small beta],[small beta]-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,5883-5890
DOI: 10.1039/C4OB01085J, PaperJeffrey Buter, Renee Moezelaar, Adriaan J. Minnaard
Palladium catalyzed asymmetric conjugate addition of ortho-substituted arylboronic acids to cyclic enones and its application in natural product synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,5995-6004
DOI: 10.1039/C4OB00830H, PaperXiaoli Wang, Linna Wang, Xiao Sheng, Zhangjian Huang, Tingting Li, Ming Zhang, Jinyi Xu, Hui Ji, Jian Yin, Yihua Zhang
Compound 8e protected against the collagen and adrenaline induced thrombosis in mice, and exhibited greater antithrombotic activity than NBP and aspirin in rats.
The content of this RSS Feed (c) The Royal Society of Chemistry

C 3-Symmetric chiral trisimidazoline-catalyzed Friedel-Crafts (FC)-type reaction

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,5827-5830
DOI: 10.1039/C4OB00925H, CommunicationShinobu Takizawa, Shuichi Hirata, Kenichi Murai, Hiromichi Fujioka, Hiroaki Sasai
The first imidazoline-catalyzed enantioselective Friedel-Crafts (FC)-type reaction was established using C3-symmetric chiral trisimidazolines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper catalyzed C-O bond formation via oxidative cross-coupling reaction of aldehydes and ethers

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00862F, CommunicationQuan Wang, Hao Zheng, Wen Chai, Dianyu Chen, Xiaojun Zeng, Renzhong Fu, Rongxin Yuan
A practical and efficient construction of C-O bonds via oxidative cross-coupling reaction of aldehydes and ethers has been realized under open air. When 2 mol% copper was used as the catalyst, various [small alpha]-acyloxy ethers were obtained with up to 93% isolated yield.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6028-6032
DOI: 10.1039/C4OB00920G, PerspectiveZhaobin Wang, Zhilong Chen, Jianwei Sun
Important progress has been made in catalytic asymmetric ring-opening of 3-substituted oxetanes, but significant challenges and opportunities remain.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot pseudo three-component reaction of nitroketene-N,S-acetals and aldehydes for synthesis of highly functionalized hexa-substituted 1,4-dihydropyridines

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6223-6238
DOI: 10.1039/C4OB00628C, PaperH. Surya Prakash Rao, A. Parthiban
Pseudo three-component condensation of aliphatic/aromatic/[small alpha],[small beta]-unsaturated aldehydes and nitroketene-N,S-acetals to afford diversely functionalized hexa-substituted 1,4-dihydropyridines under 2-aminopyridine catalysis was achieved.
The content of this RSS Feed (c) The Royal Society of Chemistry

CuI-catalyzed cross-coupling of terminal alkynes with dialkoxycarbenes: a general method for the synthesis of unsymmetrical propargylic acetals

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6215-6222
DOI: 10.1039/C4OB00614C, PaperTiebo Xiao, Ping Zhang, Yang Xie, Jun Wang, Lei Zhou
A general source of dialkoxycarbenes, 2,2-dialkoxy-5,5-dimethyl-[capital Delta]3-1,3,4-oxadiazolines, have been successfully employed as coupling partners in CuI-catalyzed cross-coupling reactions with terminal alkynes, which afforded various unsymmetrical propargylic acetals in good yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Organic synthetic transformations using organic dyes as photoredox catalysts

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6059-6071
DOI: 10.1039/C4OB00843J, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shunichi Fukuzumi, Kei Ohkubo
This review article presents various photocatalytic transformation such as oxygenation, halogenation and C-C bond formation with organic photoredox catalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6094-6104
DOI: 10.1039/C4OB00707G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael P. Storz, Giuseppe Allegretta, Benjamin Kirsch, Martin Empting, Rolf W. Hartmann
More than 60 derivatives of (2-nitrophenyl)methanol were synthesized and evaluated regarding their potency to inhibit PqsD. In vitro and in cellulo structure-activity relationships were derived.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6033-6048
DOI: 10.1039/C4OB00718B, Review ArticleLong Chen, Xiao-Ping Yin, Cui-Hong Wang, Jian Zhou
This review summarizes the recent progresses in the catalytic nucleophilic substitution of tertiary alcohols using carbon or heteroatom based nucleophiles for the efficient, diverse and atom economical construction of fully substituted carbon centres, and discusses synthetic opportunities that are still open.
The content of this RSS Feed (c) The Royal Society of Chemistry

Recent advances in the synthesis of nitroolefin compounds

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6049-6058
DOI: 10.1039/C4OB00573B, Review ArticleGuobing Yan, Arun Jyoti Borah, Lianggui Wang
This review focuses on recent achievements in nitroolefin synthesis and the mechanisms of the reactions are also discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium mediated intramolecular multiple C-X/C-H cross coupling and C-H activation: synthesis of carbazole alkaloids calothrixin B and murrayaquinone A

Org. and Biomol. Chem. - 6 hours 34 min ago

Org. Biomol. Chem., 2014, 12,6105-6113
DOI: 10.1039/C4OB00493K, PaperSrinivasan A. Kaliyaperumal, Shyamapada Banerjee, Syam Kumar U. K.
Straightforward palladium mediated syntheses of calothrixin B and murrayaquinone A are described.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.