Royal Society of Chemistry

Synthesis of oligonucleotides containing N,N-disubstituted 3-deazacytosine nucleobases by post-elongation modification and their triplex-forming ability with double-stranded DNA

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,9011-9015
DOI: 10.1039/C4OB01760A, PaperMasaaki Akabane-Nakata, Satoshi Obika, Yoshiyuki Hari
A post-elongation modification for construction of N,N-disubstituted 3-deazacytosines was developed, and a 2[prime or minute]-O,4[prime or minute]-C-methylene-bridged 3-deazacytidine analog was found for recognition of a CG base pair in triplex DNA.
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The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8803-8822
DOI: 10.1039/C4OB01652A, Review ArticleJoseph H. Lorent, Joelle Quetin-Leclercq, Marie-Paule Mingeot-Leclercq
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used in research, the cosmetic and pharmaceutical industry.
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Highly diastereoselective 1,3-dipolar cycloadditions of chiral non-racemic nitrones to 1,2-diaza-1,3-dienes: an experimental and computational investigation

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8888-8901
DOI: 10.1039/C4OB01371A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Roberta Majer, Olga Konechnaya, Ignacio Delso, Tomas Tejero, Orazio A. Attanasi, Stefania Santeusanio, Pedro Merino
Asymmetric 1,3-dipolar cycloadditions between 1,2-diaza-1,3-dienes and chiral non-racemic nitrones to give 3-substituted-5-diazenyl isoxazolidines were studied.
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Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8966-8976
DOI: 10.1039/C4OB00542B, PaperHsueh-Yun Lee, Li-Ting Wang, Yu-Hsuan Li, Shiow-Lin Pan, Yi-Lin Chen, Che-Ming Teng, Jing-Ping Liou
This study focused on the substitution effect at position C7 of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines.
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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8977-8996
DOI: 10.1039/C4OB00325J, PaperJ. Desire, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Bleriot
The synthesis and biological evaluation of a library of novel seven-membered iminosugars is reported.
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Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8877-8887
DOI: 10.1039/C4OB01338G, PaperM. Angeles Bonache, Alessandro Alaimo, Covadonga Malo, Oscar Millet, Alvaro Villarroel, Rosario Gonzalez-Muniz
Small bis-conjugates helix A329-350-PEG-triazole-PEG-helix B508-526 (41 residues), prepared through click chemistry of PEGylated peptide derivatives, bind to CaM with nanomolar affinity, behaving as mimics of the Kv7.2 native fragment (239 residues).
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NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines: a facile access to 4-trifluoromethyl-5-acylisoxazoles

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8942-8946
DOI: 10.1039/C4OB01790K, PaperLi Zhang, Qin Zeng, Ao Mao, Ziang Wu, Tian Luo, Yuanjing Xiao, Junliang Zhang
A NIS mediated sequential procedure involving oxidation and electrophilic cycloisomerization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines for 4-trifluoromethyl-5-acylisoxazole synthesis is developed.
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Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8866-8876
DOI: 10.1039/C4OB01525H, PaperBaobin Cai, Xiantao Yang, Lidan Sun, Xinmeng Fan, Liyu Li, Hongwei Jin, Yun Wu, Zhu Guan, Liangren Zhang, Lihe Zhang, Zhenjun Yang
D-/L-IsoT were used to modify the loop regions of TBA and greatly improved its bioactivity as well as stability.
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Imides modified benzopicenes: synthesis, solid structure and optoelectronic properties

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8902-8910
DOI: 10.1039/C4OB01486C, PaperDi Wu, Haojie Ge, Zhao Chen, Jinhua Liang, Jie Huang, Yufeng Zhang, Xiaoqiang Chen, Xianggao Meng, Sheng Hua Liu, Jun Yin
Imide-modified polycyclic aromatic hydrocarbons can be widely applied in the field of optoelectronic materials.
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A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans from [small alpha]-oxo ketene dithioacetals and propargyl alcohols via domino coupling/annulations

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8947-8951
DOI: 10.1039/C4OB01300J, PaperXiaobing Yang, Fangzhong Hu, Hongjing Di, Xinxin Cheng, Dan Li, Xiaoli Kan, Xiaomao Zou, Qichun Zhang
A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans 2 has been developed through the domino coupling/annulations from [small alpha]-oxo ketene dithioacetals 1 and propargyl alcohols.
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Anion binding of a neutral bis(cyclopeptide) in water-methanol mixtures containing up to 95% water

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8851-8860
DOI: 10.1039/C4OB01497A, PaperFabian Sommer, Stefan Kubik
Selectivity of a synthetic anion receptor reverses from strongly coordinating sulfate to weakly coordinating iodide anions upon increasing the water content of the solution.
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Directed arene/alkyne annulation reactions via aerobic copper catalysis

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8844-8850
DOI: 10.1039/C4OB01312C, PaperYi Zhang, Qian Wang, Huidong Yu, Yong Huang
We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen.
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Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00098F, PaperNicolas P. E. Barry, Anais Pitto-Barry, Isolda Romero-Canelon, Johanna Tran, Joan J. Soldevila-Barreda, Ian Hands-Portman, Corinne J. Smith, Nigel Kirby, Andrew P. Dove, Rachel K. O'Reilly, Peter J. Sadler
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In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00115J, PaperA. Lesniak, D. Kilinc, Suad A. Rashdan, A. von Kriegsheim, B. Ashall, D. Zerulla, W. Kolch, G. U. Lee
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A low cost synthesis method for functionalised iron oxide nanoparticles for magnetic hyperthermia from readily available materials

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00062E, PaperJoseph C. Bear, Bin Yu, Cristina Blanco-Andujar, Paul D. McNaughter, Paul Southern, Marc-Krystelle Mafina, Quentin A. Pankhurst, Ivan P. Parkin
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Design of FeBi nanoparticles for imaging applications

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00105B, PaperM. Branca, F. Pelletier, B. Cottin, D. Ciuculescu, C.-C. Lin, R. Serra, J.-G. Mattei, M.-J. Casanove, R. Tan, M. Respaud, C. Amiens
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Separation of xylenes by enclathration

Chem. Commun. - 27 October, 2014 - 15:17
Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4CC05329J, CommunicationLuigi Nassimbeni, Nikoletta B Bathori, Leena Desiree Patel, Hong Su, Edwin Weber
The isomers of xylene have been separated by enclathration using three host compounds: 9,9'-bianthryl (H1), 9,9'-spirobifluorene (H2) and trans-2,3-dibenzoylspiro[cyclopropane-1,9-fluorene] (H3). The structures of each host with a single xylene isomer...
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Tuning selectivity of triplex DNA receptors

Chem. Commun. - 27 October, 2014 - 15:17
Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4CC07805E, CommunicationHaidong Huang, Peter C Tlatelpa
Effects of hydrogen bonding clamps on the selectivity of triplex DNA receptors were studied. Incorporation of a 5-methyl-2-thiocytosine base to the parallel homopyrimidine region of a triplex receptor enabled selective...
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Is it Possible to Achieve a Complete Desaturation of Cycloalkanes Promoted by o-Benzyne?

Chem. Commun. - 27 October, 2014 - 15:17
Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4CC07311H, CommunicationFrancisco Cervantes, Abel de Cozar, Fernando Cossio, Maria Fernandez-Herrera, Gabriel Merino, Israel Fernandez
The competence between the possible reaction pathways in the reaction of different cycloalkanes and o-benzyne has been computationally explored. Systems able to undergo complete desaturation by consecutive double hydrogen atom...
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A porous metal-organic framework with -COOH groups for highly efficient pollutant removal

Chem. Commun. - 27 October, 2014 - 15:17

Chem. Commun., 2014, 50,14455-14458
DOI: 10.1039/C4CC06648K, CommunicationQi Zhang, Jiancan Yu, Jianfeng Cai, Ruijing Song, Yuanjing Cui, Yu Yang, Banglin Chen, Guodong Qian
A new metal-organic framework with -COOH groups has been realized for the complete removal of methylene blue from aqueous solution with a highest reported removal capacity of 902 mg g-1.
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