Royal Society of Chemistry

Enantioselective Synthesis of 3-Substituted 1,2-Oxazinanes Via Organocatalytic Intramolecular Aza-Michael Addition

Org. and Biomol. Chem. - 47 min 19 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01646G, CommunicationShuanghua Cheng, Shouyun Yu
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions...
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Preparation of indium nitronates and their Henry reactions

Org. and Biomol. Chem. - 47 min 19 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01468E, CommunicationRaquel G. Soengas, Rita Acurcio, Artur Silva
Indium nitronates were readily prepared from commercially available nitroalkanes by transmetalation of the corresponding lithium nitronates with indium salts. Henry reaction of this indium organometallics with aldehydes afforded [small beta]-nitroalkanols in...
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Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01669F, CommunicationTayo O. Olaleye, James A. Brannigan, Shirley M. Roberts, Robin J. Leatherbarrow, Anthony J. Wilkinson, Edward W. Tate
Peptidomimetic inhibitors of N-myristoyltransferase from malaria and leishmaniasis parasites have been designed with nanomolar potency, and reveal the first direct structural evidence for a ternary NMT/CoA/myristoyl peptide product complex.
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5-Nitroindole oligonucleotides with alkynyl side chains: universal base pairing, triple bond hydration and properties of pyrene "click" adducts

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01478B, PaperSachin A. Ingale, Peter Leonard, Haozhe Yang, Frank Seela
Universal base pairing of 5-nitroindole oligonucleotides with alkynyl and pyrene functionalized side chains was demonstrated.
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An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01564A, PaperVenkatachalam Rajeshkumar, Selvaraj Chandrasekar, Govindasamy Sekar
A novel molecular I2-catalyzed synthesis of isatins through C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones has been developed.
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Base-promoted annulation of [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01858C, CommunicationHaitao He, Chaorong Qi, Yanglu Ou, Wenfang Xiong, Xiaohan Hu, Yanwei Ren, Huanfeng Jiang
A novel direct synthesis of pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones from [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate via a base-promoted cascade annulation has been developed.
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Reversible deactivation radical polymerization mediated by cobalt complexes: recent progress and perspectives

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01427H, Review ArticleChi-How Peng, Tsung-Yao Yang, Yaguang Zhao, Xuefeng Fu
The current status and future perspective of cobalt mediated radical polymerization that showed efficient control of vinyl acetate and acrylate polymerization are described.
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An intermolecular C-H functionalization method for the synthesis of 3-hydroxy-2-oxindoles

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01643B, CommunicationJinsen Chen, Chao Song, Pei Chen, Jin Zhu
An intermolecular C-H functionalization with a denitrosation-triggered cyclization method is developed for the synthesis of 3-hydroxy-2-oxindoles.
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Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to [small beta]-ketosulfones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00776J, PaperAtul K. Singh, Ruchi Chawla, Twinkle Keshari, Vinod K. Yadav, Lal Dhar S. Yadav
A direct and efficient one-pot synthetic route to [small beta]-ketosulfones via aerobic oxysulfonylation of alkenes using thiophenols at an ambient temperature is reported.
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Regioselective [small pi]-extension of indoles with rhodium enalcarbenoids - synthesis of substituted carbazoles

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01693A, PaperKuldeep Singh Rathore, Mandeep Harode, Sreenivas Katukojvala
An efficient Rh(II) carboxylate and Bronsted acid catalyzed direct [small pi]-extension of indoles to 4-substituted carbazoles is developed.
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Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01583E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Monica Dell'Acqua, Valentina Pirovano, Giorgio Confalonieri, Antonio Arcadi, Elisabetta Rossi, Giorgio Abbiati
A modular entry to 2-propargylbenzaldehydes and their use in [small mu ]W-promoted cascade reaction with ammonium acetate for the synthesis of 3-benzylisoquinolines.
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Synthesis of substituted azafluorenones from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01629G, CommunicationNada Marquise, Vincent Dorcet, Floris Chevallier, Florence Mongin
Auto-tandem processes combining either Suzuki or Heck coupling with direct cyclizing arylation are described.
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Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01777C, PaperIshin Soehano, Lifeng Yang, Feiqing Ding, Huihua Sun, Zhen Jie Low, Xuewei Liu, Zhao-Xun Liang
Evidence are provided to support that partially reducing polyketide synthases achieve programmed ketoreduction by differential recognition of polyketide intermediates.
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Multi-channel colorimetric and fluorescent probes for differentiating between cysteine and glutathione/homocysteine

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01219D, PaperLun Song, Ti Jia, Wenjia Lu, Nengqin Jia, Weibing Zhang, Junhong Qian
Three fluorescent probes were rationally designed to discriminate between Cys and GSH/Hcy. Cys and GSH can be differentiated by the naked eye.
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Asymmetric synthesis of (3S,1[prime or minute]S)-3-(1-amino-2,2,2-trifluoroethyl)-1-(alkyl)-indolin-2-one derivatives by addition of (S)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine to 1-(alkyl)-indolin-2-ones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01453G, CommunicationPing Qian, Chen Xie, Lingmin Wu, Haibo Mei, Vadim A. Soloshonok, Jianlin Han, Yi Pan
This paper for the first time presents the addition reactions between amide-derived nucleophiles and CF3-containing N-sulfinyl-imines, with synthetically useful diastereoselectivity and chemical yields.
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Two-channel dansyl/tryptophan emitters with a cholic acid bridge as reporters for local hydrophobicity within supramolecular systems based on bile salts

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01394H, PaperM. Gomez-Mendoza, M. Luisa Marin, Miguel A. Miranda
Simultaneous emission from the Trp and Dns fluorophores of linked dyads in biomimetic media is quenched by iodide anions with rate constants that depend on the local hydrophobicity.
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ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01040J, PaperChunyong Ding, Lili Wang, Haijun Chen, Christopher Wild, Na Ye, Ye Ding, Tianzhi Wang, Mark A. White, Qiang Shen, Jia Zhou
A mild and concise approach for the construction of a 3,4-dihydro-2H-pyran ring integrated into the A-ring of the natural product oridonin is reported herein.
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A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01610F, PaperAlexandre Bruneau, Jean-Daniel Brion, Samir Messaoudi, Mouad Alami
The Pd(OAc)2/CuI system effectively catalyzes the coupling of 3-bromoquinolin-2(1H)-ones with a series of azoles to give 3-(heteroaryl)quinolin-2(1H)-ones in good yields.
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The mechanism and regioselectivity of gold(I) or platinum(II) catalyzed intramolecular hydroarylation to pyrrolopyridinones and pyrroloazepinones

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00894D, PaperRan Fang, Xiaoxiao Wei, Lizi Yang
Pyrrolopyridinones and pyrroloazepinones can be prepared through gold(I) or platinum(II) catalysis. These interesting gold(I) or platinum(II) catalyses are fully supported by a computational study justifying the formation of each intermediate.
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Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

Org. and Biomol. Chem. - 47 min 19 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01534G, PaperLi-Shi Ge, Zheng-Lin Wang, Xing-Lan An, Xiaoyan Luo, Wei-Ping Deng
Cu(II)-catalyzed addition/oxidative cyclization of thioamides with alkynoates affords structurally important 2-aminothiophenes in moderate to excellent yields.
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