Royal Society of Chemistry

Enhanced catalysis and enantioselective resolution of racemic naproxen methyl ester by lipase encapsulated within iron oxide nanoparticles coated with calix[8]arene valeric acid complexes

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6634-6642
DOI: 10.1039/C4OB01048E, PaperSerkan Sayin, Enise Akoz, Mustafa Yilmaz
In this study, two types of nanoparticles have been used as additives for the encapsulation of Candida rugosa lipase via the sol-gel method.
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An acridinium-based sensor as a fluorescent photoinduced electron transfer probe for proton detection modulated by anionic micelles

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6677-6683
DOI: 10.1039/C4OB00559G, PaperStefano Basili, Tiziana Del Giacco, Fausto Elisei, Raimondo Germani
Photoinduced electron transfer has been demonstrated to be the quenching mechanism for the fluorescent pH sensor based on the 9-amino-10-methylacridinium chromophore. The presence of anionic micelles causes a significant increase in the detection sensitivity of pH.
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SN2 regioselectivity in the esterification of 5- and 7-membered azacycloalkane quaternary salts: a DFT study to reveal the transition state ring conformation prevailing over the ground state ring strain

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6717-6724
DOI: 10.1039/C4OB00695J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Akihiro Kimura, Susumu Kawauchi, Takuya Yamamoto, Yasuyuki Tezuka
SN2 regioselectivity in 5- and 7-membered azacycloalkanes quaternary salts is directed by the transition state ring conformation.
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Synthesis and evaluation of antineurotoxicity properties of an amyloid-[small beta] peptide targeting ligand containing a triamino acid

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6684-6693
DOI: 10.1039/C4OB00959B, PaperDmytro Honcharenko, Partha Pratim Bose, Jyotirmoy Maity, Firoz Roshan Kurudenkandy, Alok Juneja, Erik Floistrup, Henrik Biverstal, Jan Johansson, Lennart Nilsson, Andre Fisahn, Roger Stromberg
A new triamino acid enables synthesis of an amyloid-[small beta] peptide (A[small beta]) targeting ligand with additional A[small beta]-ligand interactions that gives protection towards A[small beta]-induced reduction of gamma oscillations in hippocampal slice preparation.
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Azabicycles construction: the transannular ring contraction with N-protected nucleophiles

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6570-6579
DOI: 10.1039/C4OB01311E, Review ArticleAntonio Rizzo, Syuzanna R. Harutyunyan
Synthetic strategies are one of the most critical factors for the success of a synthetic campaign, but most importantly they are crucial for the economy and the efficiency of the sequence.
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Convenient access to readily soluble symmetrical dialkyl-substituted [small alpha]-oligofurans

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6661-6671
DOI: 10.1039/C4OB00898G, PaperEdward E. Korshin, Gregory M. Leitus, Michael Bendikov
A combination of heteroatom directed lithiation/CuCl2-induced homocoupling, Wittig olefination/Pd-catalyzed transfer hydrogenation followed by Suzuki-Miyaura or Stille cross-coupling enables convenient access to dialkyl-substituted [small alpha]-oligofurans of potential interest for organic electronics.
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Synthesis of methyl 2-cyano-3,12-dioxo-18[small beta]-olean-1,9(11)-dien-30-oate analogues to determine the active groups for inhibiting cell growth and inducing apoptosis in leukemia cells

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6706-6716
DOI: 10.1039/C4OB00703D, PaperXiaojing Li, Yuetong Wang, Yuan Gao, Lei Li, Xin Guo, Dan Liu, Yongkui Jing, Linxiang Zhao
A series of CDODO-Me-12 analogues were synthesized with improved ability to inhibit cell growth and induce apoptosis in HL-60 cells.
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Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6694-6705
DOI: 10.1039/C4OB00882K, PaperSankar K. Guchhait, Vikas Chaudhary
Nucleophilic activation of TMSCN as an isocyanide equivalent by DABCO-THF in the Strecker-Ugi reaction facilitates the synthesis of functional imidazoles which, as building blocks, afford access to C8-N9 annulated purines.
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Catalyst-free activation of methylene chloride and alkynes by amines in a three-component coupling reaction to synthesize propargylamines

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6725-6729
DOI: 10.1039/C4OB00986J, PaperVikas S. Rawat, Thulasiram Bathini, S. Govardan, Bojja Sreedhar
Propargylamines are synthesized via metal-free activation of the C-halogen bond of dihalomethanes and the C-H bond of terminal alkynes in a three-component coupling without catalyst or additional base and under mild reaction conditions.
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Azide-alkyne cycloaddition for universal post-synthetic modifications of nucleic acids and effective synthesis of bioactive nucleic acid conjugates

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6624-6633
DOI: 10.1039/C4OB01132E, PaperYu-Chih Su, Yu-Lun Lo, Chi-Ching Hwang, Li-Fang Wang, Min Hui Wu, Eng-Chi Wang, Yun-Ming Wang, Tzu-Pin Wang
We have developed a universal approach for post-synthetic modifications of DNA/RNA by harnessing versatile phosphoramidation and powerful azide-alkyne cycloaddition reactions.
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Copper catalyzed C-O bond formation via oxidative cross-coupling reaction of aldehydes and ethers

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6549-6553
DOI: 10.1039/C4OB00862F, CommunicationQuan Wang, Hao Zheng, Wen Chai, Dianyu Chen, Xiaojun Zeng, Renzhong Fu, Rongxin Yuan
A practical and efficient construction of C-O bonds via oxidative cross-coupling reaction of aldehydes and ethers has been realized under open air. When 2 mol% copper was used as the catalyst, various [small alpha]-acyloxy ethers were obtained with up to 93% isolated yield.
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Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Troger's bases

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6610-6623
DOI: 10.1039/C3OB42213E, PaperSamantha Murphy, Sandra A. Bright, Fergus E. Poynton, Thomas McCabe, Jonathan A. Kitchen, Emma B. Veale, D. Clive Williams, Thorfinnur Gunnlaugsson
The synthesis, spectroscopic and biological evaluation of five fluorescent Troger's bases is described. These were shown to bind to DNA, being rapidly taken up into cancer cells and induce apoptosis after 4-24 hours.
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A simple approach to pyrrolylimidazole derivatives by azirine ring expansion with imidazolium ylides

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6598-6609
DOI: 10.1039/C4OB00865K, PaperAlexander F. Khlebnikov, Olesya A. Tomashenko, Liya D. Funt, Mikhail S. Novikov
Versatile synthesis of 1-(1H-pyrrol-3-yl)-1H-imidazole derivatives by a domino reaction of 2H-azirines with 1-alkyl-3-phenacyl-1H-imidazolium bromides is reported.
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A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin

Org. and Biomol. Chem. - 12 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6590-6597
DOI: 10.1039/C4OB00935E, PaperMasato Niwa, Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa
A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds were developed to visualize transferrin-delivered intracellular labile iron.
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Molecular containers in complex chemical systems

Chem. Soc. Rev. - 12 August, 2014 - 15:17

Chem. Soc. Rev., 2014, Advance Article
DOI: 10.1039/C4CS00165F, Review ArticleSalvatore Zarra, Daniel M. Wood, Derrick A. Roberts, Jonathan R. Nitschke
This review discusses recent advances in the use of molecular containers in complex chemical systems, focusing on three aspects: host-guest behaviour, structural transformations and reactivity modulation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Strategies for interfacing inorganic nanocrystals with biological systems based on polymer-coating

Chem. Soc. Rev. - 12 August, 2014 - 15:17

Chem. Soc. Rev., 2014, Advance Article
DOI: 10.1039/C4CS00124A, Review ArticleGoutam Palui, Fadi Aldeek, Wentao Wang, Hedi Mattoussi
A representative set of nanocrystals made of semiconductors, Au and iron oxide, surface-capped with polymer ligands presenting various metal-coordinating groups.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Antibacterial polymeric nanostructures for biomedical applications

Chem. Commun. - 11 August, 2014 - 19:17

Chem. Commun., 2014, Advance Article
DOI: 10.1039/C4CC03001J, Feature ArticleJing Chen, Fangyingkai Wang, Qiuming Liu, Jianzhong Du
A topical review on recent advances in the research and applications of antimicrobial polymeric nanostructures, such as silver-decorated polymeric nanostructures, and polymeric micelles and vesicles based on antimicrobial polymers and antimicrobial peptides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach

Chem. Commun. - 11 August, 2014 - 19:17

Chem. Commun., 2014, 50,10218-10221
DOI: 10.1039/C4CC04852K, CommunicationEtienne Pair, Christophe Berini, Romain Noel, Morgane Sanselme, Vincent Levacher, Jean-Francois Briere
A novel multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction with Meldrum's acid leading to a straightforward synthesis of 1,5-diazabicyclo[3.3.0]-octane-2,6-diones upon a tandem organocatalytic regime.
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High performance asymmetrical push-pull small molecules end-capped with cyanophenyl for solution-processed solar cells

Chem. Commun. - 11 August, 2014 - 19:17

Chem. Commun., 2014, 50,10251-10254
DOI: 10.1039/C4CC04020A, CommunicationHang Gao, Yanqin Li, Lihui Wang, Changyan Ji, Yue Wang, Wenjing Tian, Xichuan Yang, Lunxiang Yin
The novel asymmetrical push-pull small molecule TPATDPPCN end-capped with cyanophenyl exhibits an impressive PCE of 5.94%.
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A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines

Chem. Commun. - 11 August, 2014 - 19:17

Chem. Commun., 2014, 50,10222-10224
DOI: 10.1039/C4CC04940C, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ho Yin Li, Joachim Horn, Amanda Campbell, David House, Adam Nelson, Stephen P. Marsden
Rh-catalysed conjugate additions of 2-aminophenyl boronic acid derivatives were exploited in diastereoselective and asymmetric syntheses of tetrahydroquinolines.
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