Royal Society of Chemistry

A Lewis acid-mediated conformational switch

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7937-7941
DOI: 10.1039/C4OB01556H, PaperPeter C. Knipe, Hannah Lingard, Ian M. Jones, Sam Thompson, Andrew D. Hamilton
An isonicotinamide-substituted diphenylacetylene undergoes conformational switching upon recognition of Lewis acids.
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Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18F-labeling

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8094-8099
DOI: 10.1039/C4OB01336K, PaperR. Richarz, P. Krapf, F. Zarrad, E. A. Urusova, B. Neumaier, B. D. Zlatopolskiy
A novel radiofluorination procedure using only precursor and [18F]fluoride without the need for azeotropic drying, base and other ingredients was developed.
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The origin of exo-stereoselectivity of norbornene in hetero Diels-Alder reactions

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8079-8086
DOI: 10.1039/C4OB01217H, PaperSesil Agopcan Cinar, Selami Ercan, Sule Erol Gunal, Ilknur Dogan, Viktorya Aviyente
The distortion of norbornene and the steric effect of the quasi-eclipsing forming bonds in the endo transition structures were demonstrated successfully in order to highlight the exo selectivity of norbornene in the reaction of 5-benzylidine-2-arylimino-3-aryl-thiazolidine-4-thiones with norbornene with the M06-2X/6-31+G(d)//B3LYP/6-31+G(d) methodology.
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Non-isoprenoid polyene natural products - structures and synthetic strategies

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7877-7899
DOI: 10.1039/C4OB01337A, Review ArticleKatrina S. Madden, Fathia A. Mosa, Andrew Whiting
This review provides insight into the variety of structures and biological activities found in the non-isoprenoid family of polyene natural products and examines the strategies and synthetic methods applied for the polyenic components in particular by way of examples.
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Enantioselective aza-Morita-Baylis-Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8072-8078
DOI: 10.1039/C4OB01358A, PaperXuan Zhao, Tian-Ze Li, Jing-Ying Qian, Feng Sha, Xin-Yan Wu
The first enantioselective aza-Morita-Baylis-Hillman reaction of acrylates with ketimines was achieved in excellent yields and good enantioselectivities.
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Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-nucleotidases

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7971-7982
DOI: 10.1039/C4OB01332H, PaperOndrej Simak, Petr Pachl, Milan Fabry, Milos Budesinsky, Tomas Jandusik, Ales Hnizda, Radka Sklenickova, Magdalena Petrova, Vaclav Veverka, Pavlina Rezacova, Jiri Brynda, Ivan Rosenberg
Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-deoxynucleotidases.
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Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8008-8018
DOI: 10.1039/C4OB01223B, PaperAhmed Kamal, Manda Sathish, Vunnam Srinivasulu, Jadala Chetna, Kunta Chandra Shekar, Shalini Nekkanti, Yellaiah Tangella, Nagula Shankaraiah
New pyrrolidinyl-oxazole-carboxamides were synthesized and utilized as efficient organocatalysts for asymmetric Michael addition reaction. In addition, computational mechanistic studies were performed.
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Multiple optical properties of a naphthoquinone pigment: 2-methyl-3-(hydroxyphenylthio)-1,4-naphthalenedione

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7965-7970
DOI: 10.1039/C4OB01058B, PaperHirotaka Akiyama, Takafumi Inoue, Nobuo Tajima, Reiko Kuroda, Yoshitane Imai
Naphthoquinone pigments 2-methyl-3-(4- or 2-hydroxyphenylthio)-1,4-naphthalenedione show characteristic multiple optical properties in solution and in the solid state.
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Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7993-8007
DOI: 10.1039/C4OB01152J, PaperAhmed Kamal, Anver Basha Shaik, Sowjanya Polepalli, Vangala Santosh Reddy, G. Bharath Kumar, Soma Gupta, K. V. S. Rama Krishna, Ananthamurthy Nagabhushana, Rakesh K. Mishra, Nishant Jain
A library of pyrazole-oxadiazole conjugates were synthesized and investigated for their antiproliferative activity in human cancer cell lines.
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Rhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7923-7926
DOI: 10.1039/C4OB01440E, CommunicationLiang Wang, Wenting Wu, Qun Chen, Mingyang He
Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group.
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Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8048-8060
DOI: 10.1039/C4OB01079E, PaperGuoxin Wang, Longjian Chen, Tongmei Xian, Yujie Liang, Xintao Zhang, Zhen Yang, Ming Luo
A series of 4-(quinolin-4-yloxy)piperidine-1-carboxylate derivatives were identified as novel and potent inhibitors of the influenza virus through structural modification of a compound from a high-throughput screen.
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An experimental and theoretical study of reaction mechanisms between nitriles and hydroxylamine

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,8036-8047
DOI: 10.1039/C4OB00854E, PaperAttila Voros, Zoltan Mucsi, Zoltan Baan, Geza Timari, Istvan Hermecz, Peter Mizsey, Zoltan Finta
The industrially relevant reaction between nitriles and hydroxylamine yielding amidoximes was studied in different molecular solvents and in ionic liquids.
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Structurally modified natural sesquiterpene lactones constitute effective and less toxic schistosomicidal compounds

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7957-7964
DOI: 10.1039/C4OB00426D, PaperDaiane Cristina Sass, Gustavo Oliveira Morais, Ricardo Augusto Crema Miranda, Lizandra Guidi Magalhaes, Wilson Roberto Cunha, Raquel Alves dos Santos, Nilton Syogo Arakawa, Fernando Batista Da Costa, Mauricio Gomes Constantino, Vladimir Constantino Gomes Heleno
Selective obtention of novel natural sesquiterpene lactone derivatives with interesting schistosomicidal activity and low toxicity, together with complete NMR assignments.
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Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection

Org. and Biomol. Chem. - 30 September, 2014 - 03:17

Org. Biomol. Chem., 2014, 12,7942-7956
DOI: 10.1039/C4OB00995A, PaperB. D. Reeves, N. Joshi, G. C. Campanello, J. K. Hilmer, L. Chetia, J. A. Vance, J. N. Reinschmidt, C. G. Miller, D. P. Giedroc, E. A. Dratz, D. J. Singel, P. A. Grieco
A protocol denoted as the thiosulfonate switch featuring sequential protein thiol blocking and conversion of protein-S-nitrosothiols to mixed disulfides bearing a fluorescent probe at pH 4.0 is reported.
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Emerging photon technologies for chemical dynamics

Faraday Disc. - 30 September, 2014 - 01:17
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00157E, PaperMajed Chergui
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Site-specific, reversible and fluorescent immobilization of proteins on CrAsH-modified surfaces for microarray analytics

Chem. Commun. - 29 September, 2014 - 08:17

Chem. Commun., 2014, 50,12761-12764
DOI: 10.1039/C4CC04120H, CommunicationJanine Schulte-Zweckel, Federica Rosi, Domalapally Sreenu, Hendrik Schroder, Christof M. Niemeyer, Gemma Triola
A novel technique for protein immobilization is presented. This approach enables an efficient, reversible and fluorogenic immobilization and the direct detection of the immobilized proteins without the need for secondary detection steps or label-free methods.
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High solid-state fluorescence in ring-shaped AEE-active tetraphenylsilole derivatives

Chem. Commun. - 29 September, 2014 - 08:17

Chem. Commun., 2014, 50,12714-12717
DOI: 10.1039/C4CC06203E, CommunicationYuanjing Cai, Kerim Samedov, Haley Albright, Brian S. Dolinar, Ilia A. Guzei, Rongrong Hu, Chaocan Zhang, Ben Zhong Tang, Robert West
Simple ring-shaped tetraphenylsilole derivatives with high solid-state fluorescence.
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Residual metallic impurities within carbon nanotubes play a dominant role in supposedly "metal-free" oxygen reduction reactions

Chem. Commun. - 29 September, 2014 - 08:17

Chem. Commun., 2014, 50,12662-12664
DOI: 10.1039/C4CC03271C, CommunicationLu Wang, Martin Pumera
ORR electrocatalysis on the supposedly metal-free carbon nanotubes is in fact due to the presence of residual metallic impurities within.
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Size-dependent patterned recognition and extraction of metal ions by a macrocyclic aromatic pyridone pentamer

Chem. Commun. - 29 September, 2014 - 08:17

Chem. Commun., 2014, 50,12730-12733
DOI: 10.1039/C4CC05197A, CommunicationJie Shen, Wenliang Ma, Lin Yu, Jin-Bo Li, Hu-Chun Tao, Kun Zhang, Huaqiang Zeng
A macrocyclic aromatic pyridine pentamer was found to exhibit patterned recognition of metal ions and efficiently extract larger ions, such as Cs+, Ba2+, Tl+, Au+, K+ and Rb+ preferentially over the other 18 smaller metal ions from the aqueous phase into the chloroform layer.
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Alkaline earth catalysis for the 100% atom-efficient three component assembly of imidazolidin-2-ones

Chem. Commun. - 29 September, 2014 - 08:17

Chem. Commun., 2014, 50,12676-12679
DOI: 10.1039/C4CC05223D, CommunicationMerle Arrowsmith, William M. S. Shepherd, Michael S. Hill, Gabriele Kociok-Kohn
A variety of functionalised imidazolidin-2-ones may be synthesised under very mild reaction conditions using non-toxic and cost-effective alkaline earth bis(amide) pre-catalysts in a 100% atom-efficient, intermolecular one-pot assembly from inexpensive alkyne and cumulene reagents.
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