Royal Society of Chemistry

BACE1 ([small beta]-secretase) inhibitors for the treatment of Alzheimer's disease

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6765-6813
DOI: 10.1039/C3CS60460H, Review ArticleArun K. Ghosh, Heather L. Osswald
The review highlights the progress in the design and development of BACE1 ([small beta]-secretase) inhibitors for the treatment of Alzheimer's disease.
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Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6859-6869
DOI: 10.1039/C4CS00047A, Review ArticleRebecca A. Kohnz, Daniel K. Nomura
This review describes the development of inhibitors for endocannabinoid metabolism and their potential therapeutic benefit.
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PET/SPECT imaging agents for neurodegenerative diseases

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6683-6691
DOI: 10.1039/C3CS60430F, Tutorial ReviewLin Zhu, Karl Ploessl, Hank F. Kung
Amyvid/PET imaging of a living brain detects [small beta]-amyloid plaque deposition, a risk factor for developing Alzheimer's disease.
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Metal complexes designed to bind to amyloid-[small beta] for the diagnosis and treatment of Alzheimer's disease

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6701-6715
DOI: 10.1039/C4CS00026A, Review ArticleDavid J. Hayne, SinChun Lim, Paul S. Donnelly
The use radioactive copper and technetium complexes as amyloid imaging agents, the use of luminescent metal complexes as non-conventional probes of amyloid formation and the potential of metal complexes to be inhibitors of amyloid toxicity are discussed.
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Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6750-6764
DOI: 10.1039/C3CS60459D, Review ArticleHyunbum Jang, Fernando Teran Arce, Srinivasan Ramachandran, Bruce L. Kagan, Ratnesh Lal, Ruth Nussinov
Aggregation of small A[small beta] oligomers into common [small beta]-sheet rich annular structural motifs is responsible for Alzheimer's disease.
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Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6814-6838
DOI: 10.1039/C3CS60467E, Review ArticleParamita Mukherjee, Maris A. Cinelli, Soosung Kang, Richard B. Silverman
Overproduction of nitric oxide by neuronal nitric oxide synthase is implicated in neurodegenerative diseases and neuropathic pain; inhibition is therapeutically desirable.
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P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6716-6726
DOI: 10.1039/C3CS60448A, Review ArticleAndrew A. Pieper, Steven L. McKnight, Joseph M. Ready
The P7C3 compounds emerged from an in vivo screen and were found to protect neurons in models of neurodegenerative disease.
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Differences between amyloid-[small beta] aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6692-6700
DOI: 10.1039/C3CS60431D, Tutorial ReviewSamuel A. Kotler, Patrick Walsh, Jeffrey R. Brender, Ayyalusamy Ramamoorthy
The association of the amyloid-[small beta] (A[small beta]) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease.
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Molecular medicine and neurodegenerative diseases

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6668-6671
DOI: 10.1039/C4CS90065K, EditorialChristopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson, Mi Hee Lim
Guest editors Christopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson and Mi Hee Lim introduce the Molecular medicine and neurodegenerative diseases themed issue of Chemical Society Reviews.
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Biological metals and metal-targeting compounds in major neurodegenerative diseases

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6727-6749
DOI: 10.1039/C4CS00138A, Review ArticleKevin J. Barnham, Ashley I. Bush
Metals are functionally essential, but redistribute in neurodegenerative disease where they induce protein aggregates, catalyze radical formation, and lose bioavailability.
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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

Chem. Soc. Rev. - 6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6839-6858
DOI: 10.1039/C4CS00038B, Review ArticleScott A. Yuzwa, David J. Vocadlo
Increasing levels of glucose responsive O-GlcNAcylation of proteins in Alzheimer disease mouse models decreases the toxicity of tau and A[small beta].
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A Mannich/Cyclization Cascade Process for the Asymmetric Synthesis of Spirocyclic Thioimida-zolidinexoindoles

Chem. Commun. - 5 October, 2014 - 09:54
Chem. Commun., 2014, Accepted Manuscript
DOI: 10.1039/C4CC06000H, CommunicationHong Liu, Yu Zhou, Hao Cai, Dong Zhang, Jinyi Xu
An asymmetric cascade Mannich/cyclization reaction be-tween 3-isothiocyanato oxindoles and sulfimide using a com-mercially available organocatalyst had been developed. A wide range of structurally diverse spiro[imidazolidine-4,3'-oxindole] derivatives were obtained with good...
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Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4CC06344A, CommunicationJie Yang, Jing Zhang, Li Qi, Chenchen Hu, Yiyun Chen
A visible-light-induced chemoselective reductive decarboxylative alkynylation for C(sp3)-C(sp) bond formation under biomolecule-compatible conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A DNA aptamer to c-Met inhibits cancer cell migration

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13131-13134
DOI: 10.1039/C4CC06016D, CommunicationR. Ueki, S. Sando
CLN0003_SL1, an optimized 50-mer DNA aptamer, suppressed the metastasis-related behaviour of cancer cells. This aptamer may be a promising molecular platform for preventing tumour development and metastasis.
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A bis-cyclometalated iridium complex as a benchmark sensitizer for efficient visible-to-UV photon upconversion

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13111-13113
DOI: 10.1039/C4CC05718J, CommunicationPengfei Duan, Nobuhiro Yanai, Nobuo Kimizuka
The biggest problem in visible-to-UV photon upconversion-the quenching of upconverted emission by sensitizers-was solved by employing a superior sensitizer with less UV absorption intensity.
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Design of anticoagulant surfaces based on cellulose nanocrystals

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13070-13072
DOI: 10.1039/C4CC05254D, CommunicationHeike M. A. Ehmann, Tamilselvan Mohan, Maria Koshanskaya, Sylvia Scheicher, Doris Breitwieser, Volker Ribitsch, Karin Stana-Kleinschek, Stefan Spirk
The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored.
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Synthesis and crystal structure of a dinuclear, monomeric MnIIp-semiquinonato complex

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13059-13061
DOI: 10.1039/C4CC06055E, CommunicationHarutaka Nakamori, Takahiro Matsumoto, Takeshi Yatabe, Ki-Seok Yoon, Hidetaka Nakai, Seiji Ogo
The first crystal structure of a monomeric p-semiquinonato d-block complex and its reactivity toward dioxygen are described.
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Assembly of antimony doped tin oxide nanocrystals into conducting macroscopic aerogel monoliths

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13138-13141
DOI: 10.1039/C4CC05648E, CommunicationFelix Rechberger, Gabriele Ilari, Markus Niederberger
We present the 3-dimensional assembly of preformed antimony doped tin oxide nanocrystals into conducting centimeter-sized aerogel monoliths.
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A bis(amido) ligand set that supports two-coordinate chromium in the +1, +2, and +3 oxidation states

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13062-13065
DOI: 10.1039/C4CC06615D, CommunicationIrene C. Cai, Michael I. Lipschutz, T. Don Tilley
A bulky silylamido ligand has been used to support low-coordinate chromium complexes in various oxidation states.
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Enhanced resistive switching effect upon illumination in self-assembled NiWO4 nano-nests

Chem. Commun. - 5 October, 2014 - 09:54

Chem. Commun., 2014, 50,13142-13145
DOI: 10.1039/C4CC05784H, CommunicationBai Sun, Wenxi Zhao, Lujun Wei, Hongwei Li, Peng Chen
The self-assembled NiWO4 nanosheet array is synthesized by a hydrothermal process, and a white-light controlled resistive switching memory device is demonstrated.
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