Royal Society of Chemistry

Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1022-1029
DOI: 10.1039/C4OB02108H, PaperD. Hernandez-Alonso, S. Zankowski, L. Adriaenssens, P. Ballester
An aryl-extended calix[4]pyrrole receptor with four carboxylic groups at the lower rim binds N-oxides in water with high stability constants.
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Investigation of end processing and degradation of premature tRNAs and their application to stabilization of in vitro transcripts in wheat germ extract

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1008-1012
DOI: 10.1039/C4OB02221A, CommunicationAtsushi Ogawa, Yasunori Doi
We investigated the end processing and degradation of premature tRNAs in wheat germ extract (left), which led to the findings of end protectors for efficiently stabilizing an in vitro transcript (purple, right).
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Developing piperine towards TRPV1 and GABAA receptor ligands - synthesis of piperine analogs via Heck-coupling of conjugated dienes

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,990-994
DOI: 10.1039/C4OB02242D, CommunicationLaurin Wimmer, David Schonbauer, Peter Pakfeifer, Angela Schoffmann, Sophia Khom, Steffen Hering, Marko D. Mihovilovic
Synthetic analogs of piperine, the pungent alkaloid of black pepper, were identified as selective ligands for either GABAA or TRPV1 receptors.
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An expedient approach to 1,2-dihydroisoquinoline derivatives via cobalt catalysed 6-endo dig cyclization followed by Mannich condensation of o-alkynylarylaldimines

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1000-1007
DOI: 10.1039/C4OB02036G, Communication Urvashi, Gaurav K. Rastogi, Sandeep K. Ginotra, Alka Agarwal, Vibha Tandon
A highly effective 6-endo dig cyclisation of o-alkynyl aldimines to 1,2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst.
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Ruthenium-catalyzed direct C3 alkylation of indoles with [small alpha],[small beta]-unsaturated ketones

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1254-1263
DOI: 10.1039/C4OB02124J, PaperShuai-Shuai Li, Hui Lin, Xiao-Mei Zhang, Lin Dong
In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various [small alpha],[small beta]-unsaturated ketones without chelation assistance has been developed.
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Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1243-1248
DOI: 10.1039/C4OB01844C, PaperHaipin Zhou, Kuo Gai, Aijun Lin, Jinyi Xu, Xiaoming Wu, Hequan Yao
A palladium-catalyzed oxidative cross-coupling reaction between azole-4-carboxylates and indoles forming 5-(3-indolyl)azoles with excellent regioselectivity has been developed.
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Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1249-1253
DOI: 10.1039/C4OB02377C, PaperH. Muchalski, L. Xu, N. A. Porter
We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins. In TMP of 7-DHC and deuterium-reinforced 7-DHC, the KIE of removing hydrogen/deuterium at C9 was found to be 21 +/- 1.
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Metal-catalyzed formation of 1,3-cyclohexadienes: a catalyst-dependent reaction

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1225-1233
DOI: 10.1039/C4OB01922A, PaperShifa Zhu, Xiaobing Huang, Tian-Qi Zhao, Tongmei Ma, Huanfeng Jiang
A metal-dependent and complementary catalytic method to synthesize the cyclohexadienes has been developed. When gold or indium salts were used as catalysts, 1,3-cyclohexadiene (1,3-CHD) could be obtained; when Cu(OTf)2 was used as the catalyst, however, another isomer 2,4-cyclohexadiene (2,4-CHD) was furnished instead.
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Fluorescent organic nanoparticles of dihydropyrimidone derivatives for selective recognition of iodide using a displacement assay: application of the sensors in water and biological fluids

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1204-1212
DOI: 10.1039/C4OB02152E, PaperAmanpreet Kaur, Tilak Raj, Simanpreet Kaur, Narinder Singh, Navneet Kaur
Fluorescent organic nanoparticles (FON's) derived from dihydropyrimidone derivatives (1-4) were developed and evaluated for their sensor properties.
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Probing coiled-coil assembly by paramagnetic NMR spectroscopy

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1159-1168
DOI: 10.1039/C4OB02125H, PaperTingTing Zheng, Aimee Boyle, Hana Robson Marsden, Dayenne Valdink, Giuliana Martelli, Jan Raap, Alexander Kros
Here a new method to determine the orientation of coiled-coil peptide motifs is described.
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Gold-catalyzed spiro-N,O-ketal synthesis

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1169-1178
DOI: 10.1039/C4OB02050B, PaperM. Grammatikopoulou, S. Thysiadis, V. Sarli
An efficient method for the synthesis of spiro-N,O-ketals with 5- and 6-membered rings was developed via a gold-catalyzed spiroamidoketalization of alkynyl amidoalcohols under mild conditions.
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Label-free fluorescence detection of kinase activity using a gold nanoparticle based indicator displacement assay

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1198-1203
DOI: 10.1039/C4OB02052A, PaperCristian Pezzato, Davide Zaramella, Massimiliano Martinelli, Gregory Pieters, Mario A. Pagano, Leonard J. Prins
A straightforward fluorescence indicator-displacement assay (IDA) has been developed for the quantitative analysis of ATP[rightward arrow]ADP conversion.
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Synthesis of isoxazolidine-containing uridine derivatives as caprazamycin analogues

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1187-1197
DOI: 10.1039/C4OB02142H, PaperMayumi Yamaguchi, Akira Matsuda, Satoshi Ichikawa
Simplification of caprazamycins was conducted by scaffold-hopping of the structurally complex diazepanone moiety to the isoxazolidine scaffold.
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Enantioselective synthesis of benzoindolizidine derivatives using chiral phase-transfer catalytic intramolecular domino aza-Michael addition/alkylation

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1179-1186
DOI: 10.1039/C4OB02227K, PaperJiajia Guo, Shouyun Yu
An efficient and enantioselective strategy to synthesize benzoindolizidines via domino intramolecular aza-Michael addition/alkylation was developed.
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Synthesis and tautomerization of hydroxylated isoflavones bearing heterocyclic hemi-aminals

Org. and Biomol. Chem. - 13 January, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,1053-1067
DOI: 10.1039/C4OB02137A, PaperMykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Volodymyr P. Khilya, Chunming Liu, David S. Watt, Vitaliy M. Sviripa
Aminomethylation of 7-hydroxy isoflavones with C2-C5 [small omega]-aminoalcohols led to tautomers 4 and 5 that were interconverted as confirmed by NMR studies.
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Trioctylphosphine as self-assembly inducer

Faraday Disc. - 13 January, 2015 - 03:17
Faraday Discuss., 2014, Accepted Manuscript
DOI: 10.1039/C4FD00248B, PaperGunadhor Singh Okram, Jaiveer Singh, Netram Kaurav, Niranjan Prasad Lalla
Nickel nanoparticles (NPs) of different shapes and sizes in the polydispersed as well as monodispersed forms were synthesized using trioctylphosphine (TOP), triphenylphosphine (TPP), oleylamine (OA) and their combinations as surfactants...
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FD-2015 Nanoparticle: Changing the Magnetic Properties of Microstructure by Directing the Self-assembly of Superparamagnetic Nanoparticles

Faraday Disc. - 13 January, 2015 - 03:17
Faraday Discuss., 2014, Accepted Manuscript
DOI: 10.1039/C4FD00245H, PaperSuvojit Ghosh, Ishwar K. Puri
Magnetic nanoparticles (MNPs) in a liquid dispersion can be organized through controlled self-assembly by applying an external magnetic field that regulates inter-particle interactions. Thus, micro- and nanostructures of desired morphology...
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Niobium-Nitrides Derived from Nitrogen Splitting

Chem. Commun. - 12 January, 2015 - 11:17
Chem. Commun., 2015, Accepted Manuscript
DOI: 10.1039/C4CC09563D, CommunicationKeith Searles, Patrick Carroll, Chun-Hsing Chen, Maren Pink, Daniel J Mindiola
The easy-to-prepare Nb(V) aryloxide complex [(ArO)2Nb(mu-Cl)Cl2]2 (OAr = 2,6-bis(diphenylmethyl)-4-tert-butylphenoxide) is a precursor to both Nb(IV), [trans-(ArO)2NbCl2(THF)2], and Nb(III), K3[(ArO)4Nb2(mu-Cl)3Cl2], molecules. The Nb(IV) and (V) complexes readily split atmospheric nitrogen at...
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Hyperbranched crystalline nanostructure produced from ionic [small pi]-conjugated molecules

Chem. Commun. - 12 January, 2015 - 11:17

Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4CC09288K, CommunicationJeremy R. Eskelsen, Kara J. Phillips, K. W. Hipps, Ursula Mazur
We report the first synthesis of a hyperbranched sheaf-like nanostructure by ionic self-assembly of organic semiconductors that forms via combined oriented attachment and Ostwald ripening growth mechanisms.
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Direct cross-coupling of benzyl alcohols to construct diarylmethanes via palladium catalysis

Chem. Commun. - 12 January, 2015 - 11:17

Chem. Commun., 2015, Advance Article
DOI: 10.1039/C4CC10084K, CommunicationZhi-Chao Cao, Da-Gang Yu, Ru-Yi Zhu, Jiang-Bo Wei, Zhang-Jie Shi
A direct arylation to furnish diarylmethanes from benzyl alcohols was realized through Pd(PPh3)4-catalyzed Suzuki-Miyaura coupling via benzylic C-O activation in the absence of any additives. The arylation is compatible with various functional groups. This development provides an atom- and step-economic way to approach a diarylmethane scaffold under mild and environmentally benign conditions.
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