Royal Society of Chemistry

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01849D, PaperBrett Schwartz, Tina Skinner-Adams, Katherine T Andrews, Mark Coster, Michael Edstein, Donna MacKenzie, Susan Charman, Maria Koltun, Scott Blundell, Anna Campbell, Rebecca Pouwer, Ron Quinn, Karren Beattie, Peter C Healy, Rohan A Davis
A series of amide (8-32, 40-45) and urea (33, 34, 36-39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against...
The content of this RSS Feed (c) The Royal Society of Chemistry

Linear dialdehydes as promising substrates for aminocatalyzed transformations

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01805B, Review ArticleIndresh Kumar, Panduga Ramaraju, Nisar A. Mir, Anoop Singh
Organocatalytic domino reactions involving amine activation of carbonyl compounds have become the latest chemical technology towards the designing and development of useful synthetic methods. In this direction, linear dialdehydes such...
The content of this RSS Feed (c) The Royal Society of Chemistry

Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The undecapeptide KKLFKKILKKL-NH2 (BP16) is a non-toxic cell-penetrating peptide (CPP) that mainly internalizes cancer cells through a clathrin dependent endocytic mechanism and localizes in late endosomes. Moreover, this CPP is...
The content of this RSS Feed (c) The Royal Society of Chemistry

Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01823K, PaperAlexander Olegovich Terent'ev, Mikhail Yur'evich Sharipov, Igor Krylov, Darya V. Gaidarenko, Gennady Nikishin
A method was developed for the bisperoxidation of styrenes with tert-butyl hydroperoxide in the presence of a catalytic amount of manganese(III) acetate. It was shown that compounds of manganese in...
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of end processing and degradation of premature tRNAs and their application to stabilization of in vitro transcripts in wheat germ extract

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02221A, CommunicationAtsushi Ogawa, Yasunori Doi
We investigated the end processing and degradation of premature tRNAs in wheat germ extract (WGE), which led to the discovery of end protectors useful for stabilizing an in vitro transcript...
The content of this RSS Feed (c) The Royal Society of Chemistry

Divergolide Congeners Illuminate Alternative Reaction Channels for Ansamycin Diversification

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02244K, CommunicationLing Ding, Jakob Franke, Christian Hertweck
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cu-Catalyzed arylation of amino group in the indazole ring: Regioselective synthesis of pyrazolo-carbazoles

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02044H, PaperK AnilKumar, Prakash Kannaboina, Devendra Kumar Dhaked, Ram A Vishwakarma, Prasad. V. Bharatam, Parthasarathi Das
Cu (II)-Catalyzed cross-coupling of various aryl boronic acids with 5 and 6-amino indazoles has resulted the (arylamino)-indazoles. These resulted (arylamino)-indazoles have been utilized in synthesizing medicinally important pyrazole fused-carbazoles via...
The content of this RSS Feed (c) The Royal Society of Chemistry

Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01898B, PaperLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
Hansen solubility parameters (HSP) have found their greatest use in the evaluation of solvent-polymer chemical interactions. Given their great interest in the scientific community, host-guest interactions in metal-organic frameworks (MOFs),...
The content of this RSS Feed (c) The Royal Society of Chemistry

Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony Bishop, Artur Krezel
Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein...
The content of this RSS Feed (c) The Royal Society of Chemistry

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Quorum sensing (QS) via the synthesis and detection of N-acyl L-homoserine lactone (AHL) signals regulates important pathogenic and mutualistic phenotypes in many bacteria. Over the past two decades, the development...
The content of this RSS Feed (c) The Royal Society of Chemistry

Reactivity of aldehydes at the Air-Water Interface. Insights from molecular dynamics simulations and ab initio calculations.

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02029D, PaperMarilia T.C. Martins-Costa, Francisco F. Garcia-Prieto, Manuel F. Ruiz-Lopez
Understanding the influence of solute-solvent interactions on chemical reactivity has been a subject of intense research in the last decades. Theoretical studies have focused on bulk solvation phenomena and a...
The content of this RSS Feed (c) The Royal Society of Chemistry

Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02383H, PaperDaniel Gryko, Marzena Banasiewicz, Dikhi Firmansyah
Anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles in reasonable yields. The yield of the key step (K, toluene, O2)...
The content of this RSS Feed (c) The Royal Society of Chemistry

Domino Reaction Involving the Bestmann-Ohira Reagent and [small alpha],[small beta]-Unsaturated Aldehydes: Efficient Synthesis of functionalized pyrazoles

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02365J, PaperShakir Ahamad, Ashis Kumar Gupta, Ruchir Kant, Kishor Mohanan
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and [small alpha],[small beta]-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles. This reaction demonstrates the dual...
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02277G, PaperAhmed Kamal, Rahim Abdul, Sd Riyaz, Poornachandra Y, Balakrishna Moku, Ganesh Kumar C., Ali S. M. Hussaini, Sridhar Balasubramanian, Pavan Kumar Machiraju
2-Styryl quinolines (9a-l) have been synthesized regioselectively from 2-methyl-quinoline by using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains....
The content of this RSS Feed (c) The Royal Society of Chemistry

Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and nitro-Mannich reactions

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02233E, PaperValentine Nenajdenko, M Vovk, Volodymyr Andriyovych Sukach, Viktor Mykolayovych Tkachuk, K Kovalchuk
Regioselective base-catalyzed addition of nitromethane to 2-oxo-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylates is reported. It was found that Michael-like pathway is highly reversible and substantially dominating under conditions of kinetic control (0-5 [degree]C, 10 h)...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02385D, PaperXiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li, Hong-Bin Zhang, Xiao-Dong Yang
A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence...
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of the Passerini and Ugi Reactions in [small beta]-Lactam Aldehydes. Synthetic Applications

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02289K, PaperBenito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, Maria Pilar Ruiz, M. Rosario Torres
Passerini (P-3CR) and Ugi (U-4CR) reactions were investigated in 4-oxoazetidine-2-carboxaldehydes affording the corresponding Passerini and Ugi adducts with moderate diastereoselectivity in high yields. Fortunately, the obtained mixtures of isomers syn/anti...
The content of this RSS Feed (c) The Royal Society of Chemistry

Molecular recognition of upper rim functionalized cavitand and its unique dimeric capsule in the solid state

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02251C, PaperTakeharu HAINO, Ryo Sekiya, Mutsumi Kobayashi, Mei Takatsuka
Cavitand 1 possesses four 2,2'-bipirydyl pillars on its upper rim that encapsulate small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form...
The content of this RSS Feed (c) The Royal Society of Chemistry

Development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02197E, PaperAlaksiej L. Hurski, Yuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii, Vladimir Aleksandrovich Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. An efficient one-pot procedure for the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Identification of Benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

Org. and Biomol. Chem. - 1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Ting Pan, Bing Chen, Qianwen Li, Hui Zhang, Chuan Bai
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.