Royal Society of Chemistry

From metal-organic framework to carbon: toward controlled hierarchical pore structures via a double-template approach

Chem. Commun. - 11 October, 2014 - 11:17

Chem. Commun., 2014, 50,13502-13505
DOI: 10.1039/C4CC06212D, CommunicationJian-Ke Sun, Qiang Xu
For the first time, MOF-derived hierarchically porous carbons with controlled pore structures have been achieved via a double-template approach.
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Synthesis and characterisation of glucosamine-NSAID bioconjugates

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8325-8335
DOI: 10.1039/C4OB01681E, PaperRachel A. Jones, Yann Thillier, Siva S. Panda, Nicole Rivera Rosario, C. Dennis Hall, Alan R. Katritzky
Synthetic strategies to prepare non-steroidal anti-inflammatory drug-glucosamine bioconjugates.
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Synthesis of enantiomerically enriched indolines and tetrahydroisoquinolines from (S)-amino acid-derived chiral carbocations: an easy access to (3S,4R)-demethoxy-3-isopropyl diclofensine

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8318-8324
DOI: 10.1039/C4OB00922C, PaperSudipta Kumar Manna, Gautam Panda
Enantiomerically enriched indolines and tetrahydroisoquinolines were synthesized in high yields from easily accessible (S)-amino acid-derived chiral carbocations.
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Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8132-8137
DOI: 10.1039/C4OB01669F, CommunicationTayo O. Olaleye, James A. Brannigan, Shirley M. Roberts, Robin J. Leatherbarrow, Anthony J. Wilkinson, Edward W. Tate
Peptidomimetic inhibitors of N-myristoyltransferase from malaria and leishmaniasis parasites have been designed with nanomolar potency, and reveal the first direct structural evidence for a ternary NMT/CoA/myristoyl peptide product complex.
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Performance of DFT methods and origin of stereoselectivity in bipyridine N,N[prime or minute]-dioxide catalyzed allylation and propargylation reactions

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8346-8353
DOI: 10.1039/C4OB01719F, PaperDiana Sepulveda, Tongxiang Lu, Steven E. Wheeler
It is shown that many DFT methods correctly predict the stereoselectivity of bipyridine N,N[prime or minute]-dioxide catalyzed alkylation reactions despite predicting the incorrect low-lying transition state structures. A novel explanation of the origin of stereoselectivity in these reactions is also provided.
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Base-promoted annulation of [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8128-8131
DOI: 10.1039/C4OB01858C, CommunicationHaitao He, Chaorong Qi, Yanglu Ou, Wenfang Xiong, Xiaohan Hu, Yanwei Ren, Huanfeng Jiang
A novel direct synthesis of pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones from [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate via a base-promoted cascade annulation has been developed.
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Synthesis of substituted azafluorenones from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8138-8141
DOI: 10.1039/C4OB01629G, CommunicationNada Marquise, Vincent Dorcet, Floris Chevallier, Florence Mongin
Auto-tandem processes combining either Suzuki or Heck coupling with direct cyclizing arylation are described.
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Oxidative damage of aromatic dipeptides by the environmental oxidants NO2[radical dot] and O3

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8280-8287
DOI: 10.1039/C4OB01577K, PaperL. F. Gamon, J. M. White, U. Wille
Irreversible oxidative damage at both aromatic side chains and dipeptide linkage occurs in aromatic N- and C-protected dipeptides upon exposure to the environmental pollutants NO2[radical dot] and O3.
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Enantioselective total syntheses of the proposed structures of prevezol B and evaluation of anti-cancer activity

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8239-8246
DOI: 10.1039/C4OB01662A, PaperAnna E. Leung, Riccardo Rubbiani, Gilles Gasser, Kellie L. Tuck
The first enantioselective total syntheses of the proposed structures of the natural product prevezol B are reported. This work has shown that the proposed structures of prevezol B are incorrect.
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Investigation of desilylation in the recognition mechanism to fluoride by a 1,8-naphthalimide derivative

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8275-8279
DOI: 10.1039/C4OB01500B, PaperJeeun Woo, Gunwoo Kim, Kevanie Quintero, Michael P. Hanrahan, Hector Palencia, Haishi Cao
Desilylation based fluorescence sensor (AF-1) gives a dual signal for quantitative detection of F- in MeCN.
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Annulated and bridged tetrahydrofurans from alkenoxyl radical cyclization

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8288-8307
DOI: 10.1039/C4OB01266F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christine Schur, Harald Kelm, Thomas Gottwald, Arne Ludwig, Rainer Kneuer, Jens Hartung
4-Pentenoxyl radicals sharing two or more carbon atoms with a cycloalkane cyclize in a predictable manner stereoselectively and regioselectively to afford in solutions of bromotrichloromethane cycloalkyl-fused or -bridged 2-bromomethyltetrahydrofurans in up to 95% yield.
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Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

Org. and Biomol. Chem. - 10 October, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,8204-8211
DOI: 10.1039/C4OB00978A, PaperJiuxi Chen, Leping Ye, Weike Su
Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines and 7-benzoylindoles.
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Photoinduced charge and energy transfer in molecular wires

Chem. Soc. Rev. - 10 October, 2014 - 04:17

Chem. Soc. Rev., 2014, Advance Article
DOI: 10.1039/C4CS00221K, Tutorial ReviewMelina Gilbert, Bo Albinsson
This tutorial review focuses on photo-induced charge/energy transfer in covalently linked donor-bridge-acceptor (D-B-A) systems.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Facile synthesis of 3D Pd-P nanoparticle networks with enhanced electrocatalytic performance towards formic acid electrooxidation

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13451-13453
DOI: 10.1039/C4CC03282A, CommunicationJingfang Zhang, You Xu, Bin Zhang
3D Pd-P nanoparticle networks (NNs) have been successfully synthesized using a facile one-step soft-template-assisted method. The as-prepared Pd-P NNs exhibit markedly improved activity and stability towards formic acid electrooxidation over Pd NNs, commercial Pd/C and Pd-P nanoparticle aggregates (NAs).
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A domino desulfurative coupling-acylation-hydration-Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13555-13558
DOI: 10.1039/C4CC05090H, CommunicationZhong-Fei Yan, Zheng-Jun Quan, Yu-Xia Da, Zhang Zhang, Xi-Cun Wang
A domino desulfurative coupling-acylation-hydration and Michael addition sequence has been established. The process involves the formation of two C-C bonds, one C-N bond and a C[double bond, length as m-dash]O double bond to produce one ring simultaneously.
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A naked-eye and ratiometric near-infrared probe for palladium via modulation of a [small pi]-conjugated system of cyanines

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13525-13528
DOI: 10.1039/C4CC05871B, CommunicationXiaohang Wang, Zhiqian Guo, Shiqin Zhu, He Tian, Weihong Zhu
The modulation of [small pi]-conjugated electrons in cyanine dyes can result in a ratiometric fluorescence change with a large Stokes shift (270 nm), especially for realizing palladium detection in aqueous samples using indicator paper and in living cells by ratiometric mode.
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Biological stability and activity of siRNA in ionic liquids

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13457-13460
DOI: 10.1039/C4CC05086J, CommunicationRomiza R. Mazid, Upulie Divisekera, Wenjuan Yang, Vijayaraghavan Ranganathan, Douglas R. MacFarlane, Christina Cortez-Jugo, Wenlong Cheng
We found that CDP IL can significantly enhance the biological stability of siRNA. More importantly siRNA in IL can still maintain high levels of gene knockdown activity.
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Facile synthesis of PdPt nanoalloys with sub-2.0 nm islands as robust electrocatalysts for methanol oxidation

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13551-13554
DOI: 10.1039/C4CC04534C, CommunicationDa-Bing Huang, Qiang Yuan, Hong-Hui Wang, Zhi-You Zhou
The high-yield, composition-tunable PdPt nanoalloys with sub-2.0 nm islands were first achieved through a facile aqueous approach.
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Enantioselective halogenative semi-pinacol rearrangement: a stereodivergent reaction on a racemic mixture

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13461-13464
DOI: 10.1039/C4CC05923A, CommunicationFedor Romanov-Michailidis, Marion Pupier, Laure Guenee, Alexandre Alexakis
The present work describes a stereodivergent reaction in the course of which an optically inactive, racemic starting material is quantitatively de-racemized with the help of an enantiomerically pure phosphate anion.
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Visible light-induced intermolecular radical addition: facile access to [gamma]-ketoesters from alkyl-bromocarboxylates and enamines

Chem. Commun. - 9 October, 2014 - 10:54

Chem. Commun., 2014, 50,13547-13550
DOI: 10.1039/C4CC05590J, CommunicationBei Hu, Haixia Chen, Yan Liu, Wuheng Dong, Kai Ren, Xiaomin Xie, Hao Xu, Zhaoguo Zhang
A highly efficient addition of alkyl [small alpha]-bromocarboxylates to enamines by visible light-induced photoredox catalysis is reported.
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