Royal Society of Chemistry

Short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced new set of spectroscopic responses to ds-DNA secondary structure

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02169J, CommunicationMarijana Radic Stojkovic, Patryciusz Piotrowski, Carsten Schmuck, Ivo Piantanida
Novel pyrene-guanidiniocarbonyl-pyrrole dye, characterised by short, rigid linker between chromophores, interacts strongly with ds-DNA but only negligibly with ds-RNA. At neutral conditions dye strong selectivity toward AT-DNA (in respect to...
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An improved procedure to prepare 3-methyl-4-nitroalkylenethylisoxazoles and their reaction under catalytic enantioselective Michael addition with nitromethane.

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02109F, PaperMauro F A Adamo, Maria Moccia, Robert James Wells
Herein, we describe a short synthesis of 3-methyl-4-nitro-5- alkylethenyl isoxazoles and their reactivity as Michael acceptor. The title compounds reacted with nitromethane under phase-transfer catalysis to provide highly enantioenriched adducts...
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Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02317J, CommunicationSanne Bouwman, Romano Orru, E. Ruijter
We describe the conjugate addition of lithiated difluoro-methanephosphonates to a diverse range of nitroglycals as a convenient method for the highly stereoselective synthesis of fluorinated aminoglycosyl phosphonates. Our approach provides...
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Asymmetric Syntheses of Three-Membered Heterocycles Using Chiral Amide-Based Ammonium Ylides

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02318H, PaperMario Waser, Mathias Pichler, Johanna Novacek, Raphael Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Muller
The use of carbonyl-stabilised ammonium ylides to access chiral glycidic amides and the corresponding aziridines has so far been limited to racemic trans-selective protocols. We herein report the development of...
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Multicomponent one-pot synthesis of highly functionalized Pyrrole-3-carbonitriles in aqueous medium and computational study

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02229G, Paperramakanth pagadala, Devendar Reddy Kommidi, Sharavankumar Kankala, Suresh Maddila, Parvesh Singh, Brenda Moodley, Neil Koorbanally, Sreekantha Babu Jonnalagadda
One-pot green protocol in aqueous medium involving four-components is developed to synthesize highly-functionalized pyrroles in good yields. Two of the newly synthesized compounds were subjected to in silico analysis on...
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Acid-promoted transformations of 1-(diphenylphosphoryl)allenes: synthesis of novel 1,4-dihydrophosphinoline 1-oxides

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02269F, CommunicationAlexander S. Bogachenkov, Albina V. Dogadina, Vadim P. Boyarskiy, Aleksander Vasilyev
1-(Diphenylphosphoryl)alka-1,2-dienes (phosphonoallenes) in Bronsted (super)acids (TfOH, FSO3H, H2SO4) at -70  120 C for 30 min - 4 h give, at first, 3-hydroxyalk-2-en-1-yl-diphenylphosphine oxides, as kinetically favorable reaction products, that...
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Ambient temperature synthesis of [small beta],[small beta][prime or minute]-fused nickel (II) pyrrolo[1,2-a]pyrazinoporphyrins via DBSA-catalyzed Pictet-Spengler approach

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02370F, PaperMahendra Nath, Dileep Kumar Singh
A facile first synthetic strategy to construct novel [small pi]-extended [small beta],[small beta][prime or minute]-fused nickel (II) pyrrolo[1,2-a]pyrazinoporphyrins has been developed via a Pictet-Spengler reaction of newly prepared nickel (II) 2-amino-3-(pyrrol-1-yl)-5,10,15,20-tetraphenylporphyrin with various aromatic, aliphatic...
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"AND" luminescent "reactive" molecular logic gates: a gateway to multi-analyte bioimaging and biosensing

Org. and Biomol. Chem. - 7 December, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02076F, Review ArticleAnthony ROMIEU
This review outlines examples that illustrate a recent and highly innovative concept in the field of (bio)molecular sensing, namely the simultaneous multi-analyte detection using "reactive" luminescent probes that are able...
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Preparation of cycloheptane ring by nucleophilic cyclopropanation of 1,2-diketones with bis(iodozincio)methane

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,241-247
DOI: 10.1039/C4OB01474J, PaperRyosuke Haraguchi, Yoshiaki Takada, Seijiro Matsubara
The nucleophlic cyclopropanation of hexa-1,5-diene-3,4-diones with bis(iodozincio)methane afforded the Zn alkoxides of cyclohepta-2,7-diene-1,2-diols stereospecifically via Zn alkoxides of cis-dialkenylcyclopropane-1,2-diols.
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6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,77-80
DOI: 10.1039/C4OB02155J, CommunicationMuhammet Tanc, Fabrizio Carta, Andrea Scozzafava, Claudiu T. Supuran
A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms.
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Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,73-76
DOI: 10.1039/C4OB01810A, CommunicationHyeon Seok Kim, Woon Young Song, Hak Joong Kim
A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays.
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Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral [small alpha]-substituted carboxylic acids from [small alpha]-substituted [small alpha],[small beta]-unsaturated aldehydes

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,223-233
DOI: 10.1039/C4OB02282C, PaperTanja Knaus, Francesco G. Mutti, Luke D. Humphreys, Nicholas J. Turner, Nigel S. Scrutton
The development of hydrogen-borrowing biocatalytic cascades is presented and applied to the synthesis of diverse [small alpha]-chiral substituted carboxylic acids.
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The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,207-214
DOI: 10.1039/C4OB02105C, PaperSteffen Glockner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley
A flow process to access oxazolines and oxazoles via a rapid and practical protocol is described.
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Synthesis of maculalactone A and derivatives for environmental fate tracking studies

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,199-206
DOI: 10.1039/C4OB02042A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samuel L. Bader, Michael U. Luescher, Karl Gademann
Labelled probes of the antifouling natural product, maculalactone A, allow for distribution studies in Artemia salina.
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Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,178-184
DOI: 10.1039/C4OB01857E, PaperJelena Pesek, Jiri Svoboda, Martina Sattler, Stefan Bartram, Wilhelm Boland
8-HQA is generated in the gut of Noctuid larvae from tryptophan as an iron chelator to control the gut microbiome.
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Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,170-177
DOI: 10.1039/C4OB01793E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.James C. Anderson, Ian B. Campbell, Sebastien Campos, Jonathan Shannon, Derek A. Tocher
The sequential use of the conjugate addition nitro-Mannich reaction, nitro reduction and then Pd-catalyzed intramolecular cyclisation allows the concise, stereodivergent synthesis of complex indolines.
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The stability of nitrogen-centered radicals

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,157-169
DOI: 10.1039/C4OB01656D, PaperJohnny Hioe, Davor Sakic, Valerije Vrcek, Hendrik Zipse
Radical stabilization energies (RSEs) for a large variety of aminyl and protonated amine radical cations have been calculated using high-level composite procedures.
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Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,55-58
DOI: 10.1039/C4OB02106A, CommunicationMinoru Ueda, Gangqiang Yang, Yuuki Nukadzuka, Yasuhiro Ishimaru, Satoru Tamura, Yoshiyuki Manabe
Importance of the D-glycopyranoside structure for the bioactivity and target affinity of jasmonic acid glucoside.
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Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

Org. and Biomol. Chem. - 7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,142-156
DOI: 10.1039/C4OB01516A, PaperJose Maria Zapico, Anna Puckowska, Kamila Filipiak, Claire Coderch, Beatriz de Pascual-Teresa, Ana Ramos
Triazole-based inhibitors with high potency and selectivity for MMP-2 were obtained through a click chemistry approach.
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FD 178: Optical forces in nanoplasmonic systems: How do they work, what can they be useful for?

Faraday Disc. - 7 December, 2014 - 17:54
Faraday Discuss., 2014, Accepted Manuscript
DOI: 10.1039/C4FD00224E, PaperOlivier Martin, T.V. Raziman, R.I. Wolke
In this article, we share our vision for a future nanofactory, where plasmonic trapping is used to control the different manufacturing steps associated with the transformation of initial nanostructures to...
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