Royal Society of Chemistry

The effect of terminal groups of viologens on their binding behaviors and thermodynamics upon complexation with sulfonated calixarenes

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5432-5443
DOI: 10.1039/C5OB00053J, PaperKui Wang, Si-Yang Xing, Xiu-Guang Wang, Hong-Xi Dou
The effect of terminal groups of viologens on their binding behaviors with sulfonated calixarenes was systematically studied in this study.
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Gold(I)-catalyzed hydroindolylation of allenyl ethers

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5358-5362
DOI: 10.1039/C5OB00635J, CommunicationChandrababu Naidu Kona, Mahesh H. Shinde, Chepuri V. Ramana
Nucleophilicity game: the gold(I)-catalyzed reaction/rearrangement of allenyl ethers has been investigated in the presence of indoles. The reaction outcome seems to be decided mainly by the nature of the pendant group of allenyl ether. Control experiments are indicative of an inner sphere mechanism for the hydroindolylation reaction.
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Pd(II)-catalyzed C(sp3)-H arylation of amino acid derivatives with click-triazoles as removable directing groups

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5444-5449
DOI: 10.1039/C5OB00066A, PaperGuofu Zhang, Xiaoqiang Xie, Jianfei Zhu, Shasha Li, Chengrong Ding, Ping Ding
An effective Pd(II)-catalyzed C(sp3)-H arylation of amino acid derivatives using 1,2,3-triazoles as removable directing groups has been developed.
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An ESIPT-based fluorescent probe for sensitive detection of hydrazine in aqueous solution

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5344-5348
DOI: 10.1039/C5OB00209E, CommunicationJi Zhou, Ruiyan Shi, Jianxu Liu, Rui Wang, Yufang Xu, Xuhong Qian
A fluorescent probe for sensitive detection of hydrazine based on an ESIPT mechanism and a substitution-cyclization-elimination cascade was developed.
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Tandem Prins/Wagner/Ritter process for the stereoselective synthesis of (3-oxabicyclo[4.2.0]octanyl)amide and (1-(5-aryltetrahydrofuran-3-yl)cyclobutyl)amide derivatives

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5532-5536
DOI: 10.1039/C5OB00031A, PaperB. V. Subba Reddy, K. Muralikrishna, J. S. Yadav, N. Jagdeesh Babu, K. Sirisha, A. V. S. Sarma
A novel synthesis of 4-aryl-(3-oxabicyclo[4.2.0]octan-1-yl)amide and (1-(5-aryltetrahydrofuran-3-yl)cyclobutyl)amide derivatives was achieved through a sequential Prins/Wagner/Ritter process.
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Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5520-5531
DOI: 10.1039/C5OB00354G, PaperSandy Desrat, Camille Remeur, Fanny Roussi
The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer.
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1,5-Benzodiazepine derivatives as potential antimicrobial agents: design, synthesis, biological evaluation, and structure-activity relationships

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5497-5509
DOI: 10.1039/C5OB00655D, PaperLan-Zhi Wang, Xiao-Qing Li, Ying-Shuang An
36 novel 1,5-benzodiazepine derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The results revealed that most of the 1,5-benzodiazepine derivatives exhibited considerable potency against all of the tested strains.
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Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine to construct deep-blue-emitting luminophores

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5372-5375
DOI: 10.1039/C5OB00552C, CommunicationJie Wu, Qiulin You, Jingbo Lan, Qiang Guo, Xiaoyu Li, Ying Xue, Jingsong You
An efficient protocol for the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines has been developed via Cu-catalysed direct C-H (hetero)arylation. The resulting compounds exhibit deep-blue emission with high quantum yields, photostability, and thermal stability.
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Application of optically active chiral bis(imidazolium) salts as potential receptors of chiral dicarboxylate salts of biological relevance

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5450-5459
DOI: 10.1039/C5OB00348B, PaperLaura Gonzalez-Mendoza, Jorge Escorihuela, Belen Altava, M. Isabel Burguete, Santiago V. Luis
New chiral ionic liquids as receptors for dicarboxylic acid derivatives.
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A short synthesis of (+/-)-antroquinonol in an unusual scaffold of 4-hydroxy-2-cyclohexenone

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5510-5519
DOI: 10.1039/C5OB00411J, PaperChe-Sheng Hsu, Ho-Hsuan Chou, Jim-Min Fang
A short synthesis of the anticancer agent antroquinonol having an unusual core structure of 2,3-dimethoxy-4-hydroxycyclohex-2-enone with substituents at three contiguous stereocenters.
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Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5418-5423
DOI: 10.1039/C5OB00058K, PaperA. Udemba, G. Smith, Q.-D. Nguyen, M. Kaliszczak, L. Carroll, R. Fortt, M. J. Fuchter, E. O. Aboagye
Evasion of apoptosis is one of the six initially proposed hallmarks of cancer, and as such, a method to detect apoptosis in a tumour would be of considerable interest in both clinical trials of new cancer therapeutics, as well as for routine patient management.
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Synthesis and P-glycoprotein induction activity of colupulone analogs

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5488-5496
DOI: 10.1039/C5OB00554J, PaperJaideep B. Bharate, Yazan S. Batarseh, Abubakar Wani, Sadhana Sharma, Ram A. Vishwakarma, Amal Kaddoumi, Ajay Kumar, Sandip B. Bharate
A diprenylated acylphloroglucinol was identified as a potent P-gp inducer and showing ability to increase amyloid-beta transport across BBB, thus it is a potential anti-Alzheimer lead compound.
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Facile synthesis and stereo-resolution of chiral 1,2,3-triazoles

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5407-5411
DOI: 10.1039/C5OB00479A, PaperYe Shi, Xiaohan Ye, Qiang Gu, Xiaodong Shi, Zhiguang Song
We describe herein the first facile synthesis of chiral triazoles through side chain functionalization.
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Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5475-5487
DOI: 10.1039/C5OB00439J, PaperNisha Yadav, Taran Khanam, Ankita Shukla, Niyati Rai, Kanchan Hajela, Ravishankar Ramachandran
DNA ligases are critical components for DNA metabolism in all organisms.
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Topochemical polymerization of unsymmetrical aryldiacetylene supramolecules with nitrophenyl substituents utilizing C-H[small pi] interactions

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5467-5474
DOI: 10.1039/C5OB00435G, PaperShichao Wang, Yong Li, Hui Liu, Jinpeng Li, Tiesheng Li, Yangjie Wu, Shuji Okada, Hachiro Nakanishi
The synthesis and solid-state polymerization of unsymmetrical aryldiacetylene supramolecules with nitrophenyl substituents.
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An efficient total synthesis of leukotriene B4

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5412-5417
DOI: 10.1039/C5OB00473J, PaperKaroline Gangestad Primdahl, Jorn Eivind Tungen, Marius Aursnes, Trond Vidar Hansen, Anders Vik
A convergent and stereoselective synthesis of leukotriene B4 has been achived in 5% yield over 10 steps in the longest linear sequence.
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Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5424-5431
DOI: 10.1039/C5OB00246J, PaperJaideep B. Bharate, Samsher Singh, Abubakar Wani, Sadhana Sharma, Prashant Joshi, Inshad A. Khan, Ajay Kumar, Ram A. Vishwakarma, Sandip B. Bharate
Pyrroles showed dual inhibition of human P-gp and S. aureus Nor A efflux pump.
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Design and synthesis of analogues of natural products

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5302-5343
DOI: 10.1039/C5OB00169B, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Martin E. Maier
In this article strategies for the design and synthesis of natural product analogues are summarized and illustrated with some selected examples.
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Understanding thio-effects in simple phosphoryl systems: role of solvent effects and nucleophile charge

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5391-5398
DOI: 10.1039/C5OB00309A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexandra T. P. Carvalho, AnnMarie C. O'Donoghue, David R. W. Hodgson, Shina C. L. Kamerlin
Detailed quantum chemical calculations provide insight on the origin of large differences in experimental thio-effects for the hydrolysis of (thio)phosphodichloridates by water and hydroxide nucleophiles.
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Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Org. and Biomol. Chem. - 12 May, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,5385-5390
DOI: 10.1039/C5OB00318K, PaperElena Pazos, Cecilia Portela, Cristina Penas, M. Eugenio Vazquez, Jose L. Mascarenas
A designed disrupter of the DNA complexes of oncoproteins Fos and Jun is reported.
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