Royal Society of Chemistry

A review: microRNA detection methods

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2226-2238
DOI: 10.1039/C4OB02104E, Review ArticleTian Tian, Jiaqi Wang, Xiang Zhou
MicroRNA (miRNA) detection is of considerable significance in both disease diagnosis and in the study of miRNA function.
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Regulating exocytosis of nanoparticles via host-guest chemistry

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2474-2479
DOI: 10.1039/C4OB02433H, PaperChaekyu Kim, Gulen Yesilbag Tonga, Bo Yan, Chang Soo Kim, Sung Tae Kim, Myoung-Hwan Park, Zhengjiang Zhu, Bradley Duncan, Brian Creran, Vincent M. Rotello
Regulating exocytosis of AuNPs by using host-guest interactions between AuNPs and CB[7] molecules.
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Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2432-2436
DOI: 10.1039/C4OB02410A, PaperXiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu, Yangjie Wu
A new and generally practical synthesis of alkynylphosphonates through a palladium-catalyzed consecutive Sonogashira/deacetonative process using aryl bromides, 2-methyl-3-butyn-2-ol and H-phosphonates is developed.
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Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2464-2473
DOI: 10.1039/C4OB02041C, PaperMaarten Danial, Sebastien Perrier, Katrina A. Jolliffe
The effect of amino acid composition on the formation of transmembrane channels in lipid bilayers upon self-assembly of alt-(L,D)-[small alpha]-cyclic octapeptides has been investigated.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2407-2422
DOI: 10.1039/C4OB02397H, PaperAnna Junker, Artur K. Kokornaczyk, Annelien J. M. Zweemer, Bastian Frehland, Dirk Schepmann, Junichiro Yamaguchi, Kenichiro Itami, Andreas Faust, Sven Hermann, Stefan Wagner, Michael Schafers, Michael Koch, Christina Weiss, Laura H. Heitman, Klaus Kopka, Bernhard Wunsch
Late-stage diversification led to selective chemokine CCR2 receptor antagonists and dual-targeting CCR2/CCR5 receptor antagonists.
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Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2423-2431
DOI: 10.1039/C4OB02049A, PaperVariam Ullas Jeankumar, Rudraraju Srilakshmi Reshma, Renuka Janupally, Shalini Saxena, Jonnalagadda Padma Sridevi, Brahmam Medapi, Pushkar Kulkarni, Perumal Yogeeswari, Dharmarajan Sriram
Exploring the Gyrase ATPase platform to tailor novel anti-tubercular leads.
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Asymmetric Michael addition of [small alpha]-fluoro-[small alpha]-nitro esters to nitroolefins: towards synthesis of [small alpha]-fluoro-[small alpha]-substituted amino acids

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2350-2359
DOI: 10.1039/C4OB02486A, PaperJacek Kwiatkowski, Yixin Lu
[small alpha]-Fluoro-[small alpha]-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities.
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LNA units present in the (2[prime or minute]-OMe)-RNA strand stabilize parallel duplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA and parallel triplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA/RNA. An improved tool for the inhibition of reverse t

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2375-2384
DOI: 10.1039/C4OB02364A, PaperAnna Maciaszek, Agnieszka Krakowiak, Magdalena Janicka, Agnieszka Tomaszewska-Antczak, Milena Sobczak, Barbara Mikolajczyk, Piotr Guga
LNA units stabilize (RNA/LNA)/RP-PS-DNA/RNA triplexes and efficiently inhibit reverse transcription of target RNA.
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Vanadyl species-catalyzed complementary [small beta]-oxidative carbonylation of styrene derivatives with aldehydes

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2385-2392
DOI: 10.1039/C4OB02621G, PaperWen-Chieh Yang, Shiue-Shien Weng, Anandhan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao, Chien-Tien Chen
By judicious choice of the counter anions in the vanadyl catalysts, we can achieve [small beta]-hydroxylated and t-butyl peroxylated carbonylation of styrenes by aromatic 1[degree] and 2[degree] alkyl aldehydes in a complementary manner.
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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2453-2463
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
A novel [small pi]-extended NiII-porphyrin shows a high selectivity towards human telomeric G-quadruplexes.
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2366-2374
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, Venkitasamy Kesavan, Kurt V. Gothelf
Homopyrimidine acyclic (L)-threoninol nucleic acid (aTNA) was synthesized and found to form highly stable (L)-aTNA-DNA-(L)-aTNA and (L)-aTNA-RNA-(L)-aTNA triple helical structures.
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Benzosulfones as photochemically activated sulfur dioxide (SO2) donors

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2399-2406
DOI: 10.1039/C4OB02466D, PaperSatish R. Malwal, Harinath Chakrapani
A series of benzosulfones were synthesized and found to undergo photolysis to generate sulfur dioxide in aqueous buffer.
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Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2360-2365
DOI: 10.1039/C4OB02311K, PaperMichael S. Perryman, Matthew W. M. Earl, Sam Greatorex, Guy J. Clarkson, David J. Fox
Enantiomerically-enriched trichloromethyl-containing alcohols are transformed regioselectively into enantiomerically-enriched 1-substituted piperazinones by modified Jocic reactions.
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Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2393-2398
DOI: 10.1039/C4OB02046D, PaperYahya E. Jad, Gerardo A. Acosta, Sherine N. Khattab, Beatriz G. de la Torre, Thavendran Govender, Hendrik G. Kruger, Ayman El-Faham, Fernando Albericio
To date, DMF has been considered as the only solvent suitable for peptide synthesis.
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[small alpha]-Tocopherol derived lipid dimers as efficient gene transfection agents. Mechanistic insights into lipoplex internalization and therapeutic induction of apoptotic activity

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2444-2452
DOI: 10.1039/C4OB02063D, PaperKrishan Kumar, Bappa Maiti, Paturu Kondaiah, Santanu Bhattacharya
Dimeric cationic tocopheryl lipids for efficacious therapeutic pDNA delivery in cancer cell lines.
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Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2247-2250
DOI: 10.1039/C4OB02602K, CommunicationAlafate Adili, Zhong-Lin Tao, Dian-Feng Chen, Zhi-Yong Han
2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes with excellent yields and enantioselectivities.
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Tetrahydrofuranyl and tetrahydropyranyl protection of amino acid side-chains enables synthesis of a hydroxamate-containing aminoacylated tRNA

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2341-2349
DOI: 10.1039/C4OB02212B, PaperLester J. Lambert, Marvin J. Miller, Paul W. Huber
O-protection using tetrahydrofuranyl or tetrahydropyranyl enabled addition of a hydroxamate-containing unnatural amino acid to a suppressor tRNA, allowing subsequent site-specific incorporation of the amino acid into the transcription factor, TFIIIA.
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Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: kinetic and thermodynamic control

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2330-2340
DOI: 10.1039/C4OB02329C, PaperDaniele Castagnolo, Leonardo Degennaro, Renzo Luisi, Jonathan Clayden
Carbolithiation of vinyl thiocarbamates may proceed with the same sense of enantioselectivity with either (-)-sparteine and (+)-sparteine surrogate ligands.
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Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N-H) [small alpha]-ketoamides

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2239-2242
DOI: 10.1039/C4OB02591A, CommunicationShan Liu, Qinghe Gao, Xia Wu, Jingjing Zhang, Kerong Ding, Anxin Wu
A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones has been developed. This reaction represents a novel strategy for the synthesis of free (N-H) [small alpha]-ketoamides.
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Byproduct promoted regioselective sulfenylation of indoles with sulfinic acids

Org. and Biomol. Chem. - 16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2251-2254
DOI: 10.1039/C4OB02575J, CommunicationCong-Rong Liu, Liang-Hui Ding
An unprecedented method to synthesise 3-sulfenylindoles is demonstrated via byproduct promoted sulfenylation of indoles with sulfinic acids.
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