Royal Society of Chemistry

Bioorthogonal site-specific labeling of the 5[prime or minute]-cap structure in eukaryotic mRNAs

Chem. Commun. - 4 April, 2014 - 12:54

Chem. Commun., 2014, 50,4478-4481
DOI: 10.1039/C4CC01549E, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Josephin Marie Holstein, Daniela Schulz, Andrea Rentmeister
A chemo-enzymatic approach for site-specific labeling of 5[prime or minute]-capped RNAs based on strain-promoted azide-alkyne cycloaddition (SPAAC) was developed.
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In situ growth of a MoSe2/Mo counter electrode for high efficiency dye-sensitized solar cells

Chem. Commun. - 4 April, 2014 - 12:54

Chem. Commun., 2014, 50,4475-4477
DOI: 10.1039/C3CC49600G, CommunicationHaijie Chen, Yian Xie, Houlei Cui, Wei Zhao, Xiaolong Zhu, Yaoming Wang, Xujie Lu, Fuqiang Huang
A facile and economical MoSe2/Mo structure was in situ prepared to replace the currently preferred expensive Pt and FTO counter electrode (CE) in dye-sensitized solar cells.
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Biomimetic total synthesis of (+/-)-yezo'otogirin A

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2519-2522
DOI: 10.1039/C4OB00186A, CommunicationHiu C. Lam, Kevin K. W. Kuan, Jonathan H. George
A concise total synthesis of (+/-)-yezo'otogirin A has been achieved via its presumed biosynthetic precursor using a late-stage biomimetic oxidative radical cyclization.
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A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2584-2591
DOI: 10.1039/C3OB42512F, PaperThomas James, Paul MacLellan, George M. Burslem, Iain Simpson, J. Andrew Grant, Stuart Warriner, Visuvanathar Sridharan, Adam Nelson
A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazine, 1,4-diazepine and 1,5-diazocane scaffolds.
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Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2568-2575
DOI: 10.1039/C3OB42428F, PaperMu Cheng, Zyta M. Ziora, Karl A. Hansford, Mark A. Blaskovich, Mark S. Butler, Matthew A. Cooper
Dalbavancin, a semi-synthetic glycopeptide with enhanced antibiotic activity compared to vancomycin and teicoplanin, dimerises strongly in an anti-cooperative manner with ligand binding.
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Phosphodiesters serve as potentially tunable aglycones for fluoro sugar inactivators of retaining [small beta]-glycosidases

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2592-2595
DOI: 10.1039/C4OB00235K, PaperB. P. Rempel, S. G. Withers
2-Deoxy-2-fluoroglycosides were synthesised and tested as covalent glycosidase inactivators. [small beta]-D-Gluco-, -manno- and -galacto-configured benzyl-benzylphosphonate derivatives efficiently inactivate [small beta]-gluco-, [small beta]-manno- and [small beta]-galactosidases, while [small alpha]-gluco- and [small alpha]-manno-configured phosphate and phosphonate derivatives instead served as slow substrates for their cognate [small alpha]-glycosidases.
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The ferrocene-pyrylium dyad as a selective colorimetric chemodosimeter for the toxic cyanide and hydrogen sulfide anions in water

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2547-2551
DOI: 10.1039/C4OB00157E, CommunicationAntonia Sola, Alberto Tarraga, Pedro Molina
A pyrylium derivative showing a remarkable ability to recognize cyanide and hydrogen sulfide anions in aqueous media through two different channels, electrochemical and chromogenic, is described.
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Fructose controlled ionophoric activity of a cholate-boronic acid

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2576-2583
DOI: 10.1039/C4OB00165F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.James R. D. Brown, Inmaculada C. Pintre, Simon J. Webb
The transport of Na+ through phospholipid bilayers by Wulff-type boronic acids at pH 8.2 is reported. Concentrations of fructose greater than 5 mM strongly inhibited ionophoric activity.
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A nanomotor involves a metastable, left-handed DNA duplex

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2543-2546
DOI: 10.1039/C4OB00317A, CommunicationYingmei Li, Chuan Zhang, Cheng Tian, Chengde Mao
A metastable left-handed DNA is used to power a DNA nanomotor by non-toehold-mediated strand displacement.
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Palladium catalyzed N-H bond insertion and intramolecular cyclization cascade: the divergent synthesis of heterocyclics

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2533-2537
DOI: 10.1039/C4OB00001C, CommunicationDong Ding, Gang Liu, Guangyang Xu, Jian Li, Guoping Wang, Jiangtao Sun
A palladium-catalyzed one-pot procedure of N-H insertion and Heck cyclization/base promoted cyclization has been developed.
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Pd(II)-catalyzed oxidative alkoxycarbonylation of 2-phenoxypyridine derivatives with CO and alcohols

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2538-2542
DOI: 10.1039/C4OB00084F, CommunicationBin Liu, Huai-Zhi Jiang, Bing-Feng Shi
A Pd(II)-catalyzed oxidative alkoxycarbonylation of phenol derivatives with atmospheric pressure of CO-O2 and alcohols has been achieved.
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Copper-catalyzed benzylic C(sp3)-H alkoxylation of heterocyclic compounds

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2528-2532
DOI: 10.1039/C4OB00215F, CommunicationNoriaki Takemura, Yoichiro Kuninobu, Motomu Kanai
Intra- and intermolecular C(sp3)-H alkoxylation on a gram scale.
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Versatile C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2606-2614
DOI: 10.1039/C3OB42251H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Arne Berthelmann, Johannes Lach, Melissa A. Grawert, Michael Groll, Jutta Eichler
Attachment of foldon monomers to a trimesic acid scaffold enhances thermal stability of the trimer, while maintaining the correct fold.
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Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2615-2625
DOI: 10.1039/C3OB42308E, PaperLaxminarayan Sahoo, Anadi Singhamahapatra, Duraikkannu Loganathan
5-Halo triazole linked glycolipids, potentially useful for extraction and crystallization of integral membrane proteins synthesized by Cu(I) catalyzed click reaction.
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Molecular binding behavior of a bispyridinium-containing bis([small beta]-cyclodextrin) and its corresponding [2]rotaxane towards bile salts

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2559-2567
DOI: 10.1039/C3OB42103A, PaperYing-Ming Zhang, Ze Wang, Yong Chen, Hong-Zhong Chen, Fei Ding, Yu Liu
The molecular binding behavior of a bispyridinium-bridged bis([small beta]-cyclodextrin) and its corresponding [2]rotaxane with a series of bile salts was systematically studied, revealing a significant conformational change upon host-guest complexation.
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Isovanillin derived N-(un)substituted hydroxylamines possessing an ortho-allylic group: valuable precursors to bioactive N-heterocycles

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2552-2558
DOI: 10.1039/C3OB42460J, PaperBalakrishna Dulla, Neelima D. Tangellamudi, Sridhar Balasubramanian, Swapna Yellanki, Raghavender Medishetti, Rakesh Kumar Banote, Girish Hari Chaudhari, Pushkar Kulkarni, Javed Iqbal, Oliver Reiser, Manojit Pal
Isovannillin based N-heterocycles are synthesized and evaluated for their potential anxiogenic properties.
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Recent progress on asymmetric organocatalytic construction of chiral cyclohexenone skeletons

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2499-2513
DOI: 10.1039/C3OB42293C, Review ArticleXin Yang, Jun Wang, Pengfei Li
Chiral cyclohex-2-enones are important intermediates in synthetic chemistry as well as in the life science industries. In this focus review, recent advances in the organocatalytic asymmetric synthesis of chiral cyclohex-2-enone skeletons are summarized. The reaction mechanisms are also briefly discussed.
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A direct access to bioactive fused N-heterocyclic acetic acid derivatives

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2514-2518
DOI: 10.1039/C3OB42535E, CommunicationRaju Adepu, A. Rajitha, Dipali Ahuja, Atul Kumar Sharma, B. Ramudu, Ravikumar Kapavarapu, Kishore V. L. Parsa, Manojit Pal
A Cu-catalyzed domino reaction afforded novel fused N-heterocycles as potential PDE4 inhibitors.
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Mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde

Org. and Biomol. Chem. - 3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2523-2527
DOI: 10.1039/C3OB42431F, CommunicationJian Li, Hongni Wang, Jiangtao Sun, Yang Yang, Li Liu
A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.
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The relevance of light in the formation of colloidal metal nanoparticles

Chem. Soc. Rev. - 3 April, 2014 - 07:54

Chem. Soc. Rev., 2014, 43,2089-2097
DOI: 10.1039/C3CS60256G, Tutorial ReviewMarek Grzelczak, Luis M. Liz-Marzan
The presence of light in chemical synthesis of plasmonic nanoparticles offers promising tools for colloidal nanofabrication.
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