Royal Society of Chemistry

Lactone-fused cyclohexadiene as versatile platform for diversified synthesis of 5,6,5-tricyclic scaffolds

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00729A, CommunicationYoshihiko Yamamoto, Tomonori Sudoh, Tomoyoshi Kawamura, Masatoshi Shibuya
A lactone-fused cyclohexadiene, which can be readily prepared by the ruthenium(III)-catalyzed [2 + 2 + 2] cyclization of an enediyne, functioned as a versatile platform for the stereoselective synthesis of...
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Direct conversion of allyl arenes to aryl ethylketones via a TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00586H, CommunicationJinWu Zhao, Li Liu, ShiJian Xiang, Qiang Liu, HuoJi Chen
A TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes was developed.
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Identification of a Novel Class of Covalent Modifiers of Hemoglobin as Potential Antisickling Agents

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00367A, PaperAbdelsattar M Omar, Mona A Mahran, Mohini N Ghatge, Nadia Chowdhury, Faida H.A. Bamane, Moustafa E El-Araby, Osheiza Addulmalik, Martin Safo
Aromatic aldehydes and ethacrynic acid (ECA) exhibit antipolymerization properties that are beneficial for sickle cell disease therapy. Based on ECA pharmacophore and its atomic interaction with hemoglobin, we designed and...
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Rhodium-catalyzed denitrogenative thioacetalization of N-sulfonyl-1,2,3-triazoles with disulfides: an entry to diverse transformation of terminal alkynes

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00638D, CommunicationHao Zhang, Hui Wang, Haijun Yang, Hua Fu
An efficient and useful rhodium-catalyzed denitrogenative thioacetalization of N-sulfonyl-1,2,3-triazoles has been developed for the first time. The protocol uses readily available N-sulfonyl-1,2,3-triazoles and diaryl disulfides as the starting materials, the...
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Gold-catalyzed cascade C-H/C-H cross-coupling/cyclization/ alkynylation: An efficient access to 3-alkynylpyrroles

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00599J, CommunicationShuai Zhang, Yuanhong Ma, Jingbo Lan, Feijie Song, Jingsong You
An efficient approach to 3-alkynylpyrroles has been developed through the gold-catalyzed reaction of [small beta]-enamino derivatives with terminal alkynes, which features complete regiocontrol, relatively wide substrate scope, and high functional group...
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Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Butadiene Monoxide with Isatin Derivatives

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00663E, PaperGen Li, Xiangqing Feng, HAIFENG DU
Isatins and their derivatives are important functional moities and building blocks in pharmaceutical and synthetic chemistry. Numerous enantioselective transformations at the C-3 carbonyl group have been well developed. However, the...
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A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00315F, PaperF. Jerry Reen, Rachel Shanahan, Rafael Cano, Fergal O'Gara, Gerard P. McGlacken
Swarming motility inhibition in Bacillus atrophaeus.
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Grignard-mediated reduction of 2,2,2-trichloro-1-arylethanones

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00541H, PaperAli H. Essa, Reinner I. Lerrick, Ece Ciftci, Ross W. Harrington, Paul G. Waddell, William Clegg, Michael J. Hall
2,2,2-Trichloro-1-aryl-ethanones can be reduced by RMgX to the corresponding 2,2-dichloro-1-arylethen-1-olates and trapped with a range of electrophiles. In addition we demonstrate that 2,2-dichloro-1-arylethen-1-olates undergo counter-ion controlled Darzens condensations.
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Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: a study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP)

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02384F, PaperAnn-Marie Fanning, Sally. E. Plush, Thorfinnur Gunnlaugsson
Lanthanide(III) complexes of 'pseudo' dipeptide ligands and 3'-pyridine ligands have been characterised as metallo-ribonuclease mimics.
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Direct synthesis of a geminal zwitterionic phosphonium/hydridoborate system - developing an alternative tool for generating frustrated Lewis pair hydrogen activation systems

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00634A, PaperJiangang Yu, Gerald Kehr, Constantin G. Daniliuc, Christoph Bannwarth, Stefan Grimme, Gerhard Erker
A convenient way to a new class of geminal Mes2PH+/B(C6F5)2H- pairs is presented.
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The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

Org. and Biomol. Chem. - 6 hours 50 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00548E, PaperPavel Padnya, Elena Yushkova, Olga Mostovaya, Ildar Rizvanov, Ivan Stoikov
New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS...
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Simultaneous introduction of trifluoromethyl and [small lambda]6-pentafluorosulfanyl substituents using F5S-C[triple bond, length as m-dash]C-CF3 as a dienophile

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00610D, CommunicationBlazej Duda, Dieter Lentz
SF5-C[triple bond, length as m-dash]C-CF3 as a powerful dienophile in Diels-Alder reactions, provides the corresponding products in up to quantitative yields and allows the introduction of the pentafluorosulfanyl group and trifluoromethyl group at the 1,2 position.
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Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00650C, CommunicationMohammed Salah Ayoup, David B. Cordes, Alexandra M. Z. Slawin, David O'Hagan
A synthesis of amino acids carrying the all-cis tetrafluorocyclohexyl ring moiety is demonstrated and protection/deprotection elaborations are illustrated which show that this facially polarised ring motif may be incorporated into peptides.
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Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00576K, PaperSteven M. Wales, Katherine A. Hammer, Amy M. King, Andrew J. Tague, Dena Lyras, Thomas V. Riley, Paul A. Keller, Stephen G. Pyne
Designed binaphthyl-based, cationic peptidomimetic antimicrobials targeting C. difficile, incorporating a click-derived 1,2,3-triazole ester isostere at the C-terminus MICs of 4 [small mu ]g mL-1 against three human isolates of C. difficile.
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Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00498E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ian Paterson, Michael P. Housden, Christopher J. Cordier, Paul M. Burton, Friedrich A. Muhlthau, Olivier Loiseleur
A modular strategy for the synthesis of the immunosuppressant macrolide brasilinolide A was adopted based on coupling suitable northern and southern fragments.
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A preorganized [small beta]-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00389J, CommunicationYosuke Demizu, Makoto Oba, Koyo Okitsu, Hiroko Yamashita, Takashi Misawa, Masakazu Tanaka, Masaaki Kurihara, Samuel H. Gellman
A cyclic [small beta]-amino acid (APCGu) bearing a side-chain guanidinium group has been developed.
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High solid-state luminescence in propeller-shaped AIE-active pyridine-ketoiminate-boron complexes

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00607D, PaperYanping Wu, Zhenyu Li, Qingsong Liu, Xiaoqing Wang, Hui Yan, Shuwen Gong, Zhipeng Liu, Weijiang He
Two pyridine-ketoiminate-based organoboron complexes were demonstrated to possess aggregation-induced emission, large Stokes shift and high quantum yield in the solid-state, which were rationalized through X-ray crystal analysis and electronic structure calculations.
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Indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00277J, PaperFanmei Li, Zhilin Meng, Jing Hua, Wei Li, Hongxiang Lou, Lei Liu
An efficient indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings promoted by DDQ was described.
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Organocatalytic regioselective asymmetric Michael addition of azlactones to o-hydroxy chalcone derivatives

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00121H, PaperShao-Yun Zhang, Gui-Yu Ruan, Zhi-Cong Geng, Nai-Kai Li, Ming Lv, Yong Wang, Xing-Wang Wang
Regio- and enantio-selective Michael addition between azlactones with o-hydroxy chalcone derivatives is reported. Optically active N,O-aminals are obtained in good yields with good to excellent diastereo- and enantio-selectivities.
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Resveratrol-based benzoselenophenes with an enhanced antioxidant and chain breaking capacity

Org. and Biomol. Chem. - 6 hours 50 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00193E, PaperDamiano Tanini, Lucia Panzella, Riccardo Amorati, Antonella Capperucci, Elio Pizzo, Alessandra Napolitano, Stefano Menichetti, Marco d'Ischia
One-pot selenenylation of resveratrol with Se(0) and SO2Cl2 leads to benzoselenophene derivatives with efficient Trolox-like antioxidant and chain breaking capacity.
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