Royal Society of Chemistry

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01849D, PaperBrett Schwartz, Tina Skinner-Adams, Katherine T Andrews, Mark Coster, Michael Edstein, Donna MacKenzie, Susan Charman, Maria Koltun, Scott Blundell, Anna Campbell, Rebecca Pouwer, Ron Quinn, Karren Beattie, Peter C Healy, Rohan A Davis
A series of amide (8-32, 40-45) and urea (33, 34, 36-39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against...
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Linear dialdehydes as promising substrates for aminocatalyzed transformations

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01805B, Review ArticleIndresh Kumar, Panduga Ramaraju, Nisar A. Mir, Anoop Singh
Organocatalytic domino reactions involving amine activation of carbonyl compounds have become the latest chemical technology towards the designing and development of useful synthetic methods. In this direction, linear dialdehydes such...
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Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The undecapeptide KKLFKKILKKL-NH2 (BP16) is a non-toxic cell-penetrating peptide (CPP) that mainly internalizes cancer cells through a clathrin dependent endocytic mechanism and localizes in late endosomes. Moreover, this CPP is...
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Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01823K, PaperAlexander Olegovich Terent'ev, Mikhail Yur'evich Sharipov, Igor Krylov, Darya V. Gaidarenko, Gennady Nikishin
A method was developed for the bisperoxidation of styrenes with tert-butyl hydroperoxide in the presence of a catalytic amount of manganese(III) acetate. It was shown that compounds of manganese in...
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Investigation of end processing and degradation of premature tRNAs and their application to stabilization of in vitro transcripts in wheat germ extract

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02221A, CommunicationAtsushi Ogawa, Yasunori Doi
We investigated the end processing and degradation of premature tRNAs in wheat germ extract (WGE), which led to the discovery of end protectors useful for stabilizing an in vitro transcript...
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Preparation of polydopamine nanocapsules in a miscible tetrahydrofuran-buffer mixture

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02080D, CommunicationYun-Zhou Ni, Wen-Feng Jiang, Gang-Sheng Tong, Jian-Xin Chen, Jie Wang, Hui-Mei Li, Chun-Yang Yu, Xiao-hua Huang, Yong-Feng Zhou
A non-emulsion soft template method based on a miscible tetrahydrofuran-tris buffer mixture has been used to fabricate polydopamine nanocapsules.
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Synthesis of 3,3-dichloroindolin-2-ones from isatin-3-hydrazones and (dichloroiodo)benzene

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02213K, CommunicationKeith E. Coffey, Ryan Moreira, Farhana Z. Abbas, Graham K. Murphy
An operationally simple conversion from hydrazones to gem-dichlorides occurs with broad functional group compatibility in moderate to high yield.
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Carbocycles from donor-acceptor cyclopropanes

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02117G, Review ArticleHuck K. Grover, Michael R. Emmett, Michael A. Kerr
Donor-acceptor cyclopropane annulations - not just for heterocycles.
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Copper(I)-promoted cycloalkylation-peroxidation of unactivated alkenes via sp3 C-H functionalisation

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01962H, CommunicationArghya Banerjee, Sourav Kumar Santra, Aniket Mishra, Nilufa Khatun, Bhisma K. Patel
A copper-promoted cycloalkylation-peroxidation strategy has been developed via a three-component reaction involving cycloalkanes, tert-butyl hydroperoxide and internal conjugated alkene.
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Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02207F, PaperStefan Oschatz, Tom Brunzel, Xiao-Feng Wu, Peter Langer
A convenient and facile procedure for the synthesis of dihydroquinazolinthiones from 2-aminobenzothioamide with aldehydes has been developed. The reactions took place in water without the need of any additive.
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Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02324B, CommunicationRui Wang, John R. Falck
An efficient and asymmetric synthesis approach towards the biologically interesting molecule 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) was developed. This protocol mainly relied on our mild cross-coupling and asymmetric stannylation.
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Design and synthesis of Troger's base ditopic receptors: host-guest interactions, a combined theoretical and experimental study

Org. and Biomol. Chem. - 5 hours 25 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02266A, PaperManda Bhaskar Reddy, Myadaraboina Shailaja, Alla Manjula, Joseph Richard Premkumar, Garikapati Narahari Sastry, Katukuri Sirisha, Akella Venkata Subrahmanya Sarma
The host-guest interaction between flexible ditopic receptors and bisammonium ion has been investigated experimentally and computationally. The conformation folding of guest bisammonium ion molecules leads to the oscillation of the host-guest interaction.
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Divergolide Congeners Illuminate Alternative Reaction Channels for Ansamycin Diversification

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02244K, CommunicationLing Ding, Jakob Franke, Christian Hertweck
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring...
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Cu-Catalyzed arylation of amino group in the indazole ring: Regioselective synthesis of pyrazolo-carbazoles

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02044H, PaperK AnilKumar, Prakash Kannaboina, Devendra Kumar Dhaked, Ram A Vishwakarma, Prasad. V. Bharatam, Parthasarathi Das
Cu (II)-Catalyzed cross-coupling of various aryl boronic acids with 5 and 6-amino indazoles has resulted the (arylamino)-indazoles. These resulted (arylamino)-indazoles have been utilized in synthesizing medicinally important pyrazole fused-carbazoles via...
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Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01898B, PaperLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
Hansen solubility parameters (HSP) have found their greatest use in the evaluation of solvent-polymer chemical interactions. Given their great interest in the scientific community, host-guest interactions in metal-organic frameworks (MOFs),...
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Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony Bishop, Artur Krezel
Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein...
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Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Quorum sensing (QS) via the synthesis and detection of N-acyl L-homoserine lactone (AHL) signals regulates important pathogenic and mutualistic phenotypes in many bacteria. Over the past two decades, the development...
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Reactivity of aldehydes at the Air-Water Interface. Insights from molecular dynamics simulations and ab initio calculations.

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02029D, PaperMarilia T.C. Martins-Costa, Francisco F. Garcia-Prieto, Manuel F. Ruiz-Lopez
Understanding the influence of solute-solvent interactions on chemical reactivity has been a subject of intense research in the last decades. Theoretical studies have focused on bulk solvation phenomena and a...
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Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02383H, PaperDaniel Gryko, Marzena Banasiewicz, Dikhi Firmansyah
Anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles in reasonable yields. The yield of the key step (K, toluene, O2)...
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Domino Reaction Involving the Bestmann-Ohira Reagent and [small alpha],[small beta]-Unsaturated Aldehydes: Efficient Synthesis of functionalized pyrazoles

Org. and Biomol. Chem. - 5 hours 25 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02365J, PaperShakir Ahamad, Ashis Kumar Gupta, Ruchir Kant, Kishor Mohanan
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and [small alpha],[small beta]-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles. This reaction demonstrates the dual...
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