Royal Society of Chemistry

Tandem Prins/Pinacol reaction for the synthesis of oxaspiro[4.5]decan-1-one scaffolds

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01188K, PaperVenkata Subba Reddy Basireddy, Sama Gopal Reddy, Mittapalli Ramana Reddy, Manika Pal Bhadra, Sarma VS Akella
A novel Lewis acid catalyzed Prins/Pinacol cascade process has been developed for the synthesis of 7-substituted-8-oxaspiro[4.5]decan-1-ones in good yields with excellent selectivity. This is the first example on the synthesis...
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Benzodithiophene based [small pi]-conjugated macrocycle: synthesis, morphology and electrochemical characterizaion

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01043D, PaperSanjio S Zade, Anjan Bedi
A 7,8-didodecyloxybenzo[1,2-b:4,3-b']dithiophene (BdT-Dod) containiing macrocycle was synthesized from a thiophene capped BdT-Dod comonomer through Ti(IV) mediated McMurry reaction and characterized by 1H NMR, 13C NMR and MALDI-TOF mass spectrometry. Additionally,...
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CoPc-catalyzed selective radical arylation of anilines with arylhydrazines for synthesis of 2-aminobiaryls

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00798K, PaperTao Jiang, Sheng-Yan Chen, Guo-Yu Zhang, Run-Sheng Zeng, Jian-Ping Zou
CoPc-catalyzed selective radical arylation of anilines with arylhydrazines to afford 2-aminobiaryls in moderate to good yields is described.
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Orthogonal functionalisation of [small alpha]-helix mimetics

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00915K, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Barnard, Kerya Long, David J. Yeo, Jennifer A. Miles, Valeria Azzarito, George M. Burslem, Panchami Prabhakaran, Thomas A. Edwards, Andrew J. Wilson
We present methodology to modify N-alkylated aromatic oligoamide [small alpha]-helix mimetics using 'click' chemistry.
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Alkylene-bridged Viologen Dendrimers: A Versatile Cell Delivery Tool With Biosensing Properties

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00560K, PaperDirk Bongard, Wilhelm Bohr, Marta Swierczek, Wolfgang Nierling, Lorenz Walder, Roland Brandt
Abstract The synthesis of two types of viologen dendrimers with peripheral carboxy-groups is described. The interaction with plasmid DNA and CT-DNA, time evolution and electrolyte influence of dendriplex formation has...
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Polyalkynylanthracenes - Syntheses, Structures and their Behaviour towards UV Irradiation

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00735B, PaperNorbert Werner Mitzel, Jan-Hendrik Lamm, Beate Neumann, Andreas Mix, Jasmin Chmiel, Johanna Glatthor, Jan-Henrik Weddeling, Georg Stammler
A series of bis- and tris[(trimethylsilyl)ethynyl]anthracenes (1,5-, 1,8-, 9,10- and 1,8,10-) has been synthesised by multistep (cross coupling) reactions and the behaviour of the SiMe3-functionalised alkynylan-thracene derivatives towards UV irradiation...
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A one-pot multicomponent coupling/cyclization for natural product herbicide (+/-)-thaxtomin A

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01148A, CommunicationJean Paul Bourgault, Amarendar Reddy Maddirala, Peter R. Andreana
The herbicide (+/-)-thaxtomin A has been synthesized in a one-pot two step process through an Ugi reaction followed by base-mediated cyclization.
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Total Syntheses and Structural Validation of Lincitol A, Lincitol B, Uvacalol I, Uvacalol J, and Uvacalol K

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01329H, PaperKana M Sureshan, Soumik Mondal
Natural carbasugars are important class of biologically active compounds. Due to their conformational freedom and due to the subtle difference in spectral characteristics between isomers, often their NMR-based structural assignments...
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Effect of LNA nucleobases as an enhancer for the binding of amiloride to an abasic site in DNA/DNA and DNA/RNA duplexes

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00977K, PaperYusuke Sato, Tetsushi Sato, Takaya Sato, Seiichi Nishizawa, Norio Teramae
We report on a significant effect of locked nucleic acid (LNA) nucleobases on the binding of amiloride for abasic site (AP)-containing DNA duplexes. Fluorescence titration experiments showed that the binding...
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Direct Intermolecular C-H Arylation of Unactivated Arenes with Aryl Bromides Catalysed by 2-Pyridyl Carbinol

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01211A, CommunicationYinuo Wu, Pui Ying Choy, Fuk Yee (Michael) Kwong
Direct intermolecular C-H arylation employing aryl bromide as the arene source has been developed. This process proceeds via a simple transition-metal free pathway. With the aid of inexpensive and commercially...
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L-Rhamnose-containing supramolecular nanofibrils as a potential immunosuppressive material

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01362J, CommunicationFan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll, Bing Xu
An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, contrasting to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the...
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Microwave assisted synthesis and QSAR study of novel NSAID acetaminophen conjugates with amino acid linkers

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01281J, PaperAnand D Tiwari, Siva S Panda, AS Girgis, Sandhyamayee Sahu, Riham F George, Aladdin M Srour, Brian La Starza, Abdullah M. Asiri, Charles Dennis Hall, Alan R Katritzky
Novel, 6a-l non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates (6b,...
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Removal of amino in anilines through diazonium salt-based reactions

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01286K, Review ArticleLinman He, Guanyinsheng Qiu, Yueqiu Gao, Jie Wu
This minireview draws a conclusion on the applications of in situ generated diazonium salts from anilines in organic synthesis. In situ generation of diazonium salts from anilines represents an efficient...
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New reagents for detecting free radicals and oxidative stress

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01172D, Review ArticleMina Barzegar Amiri Olia, Carl H. Schiesser, Michelle K. Taylor
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
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An Easy Access to [small alpha]-Aryl Substituted [gamma]-Ketophosphonates: Lewis Acid Mediated Reactions of 1,3-diketones with [small alpha]-hydroxyphosphonates and Tandem Regioselective C-C Bond Cleavage

Org. and Biomol. Chem. - 6 hours 37 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01091D, PaperGangaram Pallikonda, manab chakravarty, Manoj Kumar Sahoo
A range of [small alpha]-aryl substituted [gamma]-ketophosphonates is synthesised by Lewis acid mediated reactions of 1,3-diketones and easily accessible, inexpensive benzylic [small alpha]-hydroxyphosphonates in an operationally-simple method under solvent-free conditions without exclusion...
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Total synthesis of putative montamine and a proposed structural reassignment

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01304B, PaperLachlan M. Blair, Elizabeth A. Colby Davie, Jonathan Sperry
The spectroscopic data for synthetic montamine does not match the proposed N,N[prime or minute]-linked structure and closely resembles a known 4,4[prime or minute]-bismoschamine natural product.
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E. Nielsen
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
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A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00871E, PaperShuai Fang, Xiaoyi Niu, Zeyuan Zhang, Yan Sun, Xiaomeng Si, Cuicui Shan, Lei Wei, Aiqing Xu, Lei Feng, Chen Ma
A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed.
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Recent advances in heterobimetallic palladium(II)/copper(II) catalyzed domino difunctionalization of carbon-carbon multiple bonds

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00610K, Review ArticleEgle M. Beccalli, Gianluigi Broggini, Silvia Gazzola, Alberto Mazza
The Pd(II)/Cu(II)-catalysed double functionalization of carbon-carbon multiple bonds in domino processes has emerged in recent years as a fruitful tool for the rapid synthesis of complex molecular scaffolds.
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A self-replicating peptide nucleic acid

Org. and Biomol. Chem. - 6 hours 37 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01168F, PaperTobias A. Ploger, Gunter von Kiedrowski
This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
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