Royal Society of Chemistry

N[1,3]-Sigmatropic Shift in the Benzidine Rearrangement: Experimental and Theoretical Investigation

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00080C, PaperShili Hou, Xinyao Li, Jiaxi Xu
The N[1,3]-sigmatropic shift in the benzidine rearrangement has been studied in depth experimentally with the aid of the density functional theory (DFT) calculations. The designed substituted N,N'-diaryl hydrazines rearrange exclusively...
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Continuous Flow Chemistry: A Discovery Tool for New Chemical Reactivity Patterns

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00662C, PaperSteven V Ley, Jan Benedikt Metternich, Nikzad Nikbin, Jan Hartwig, Andreas Kirschning
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied...
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Synthesis of New Asymmetric Xanthene Dyes via Catalyst-free SNAr with Sulfur Nucleophiles

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00533C, CommunicationMichaela Kotaskova, Okan Osman Oglou, Mark Helm
Addition of a single functional handle to the tricyclic moiety of fluorescein results in asymmetric xanthene dyes. Our synthesis of a new class of asymmetric xanthenes proceeds via an unusual...
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An easy route to synthetic Analogues of Radicamine B, Codonopsine and Codonopsinine from D-Mannitol

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00503A, PaperYashwant D Vankar, Suresh Dharuman, Ashok Kumar Palanivel
A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine...
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Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00622D, CommunicationJun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga, Akira Otaka
A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of...
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Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00589A, PaperHu Ge, Jinggong Liu, Wenxia Zhao, Yu Wang, Qingqing He, ruibo wu, Ding Li, Jun Xu
In the present study, we found that three enzymes, MVK, MDD, and FPPS, in mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols (...
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First total syntheses of chrestifoline-B and (+/-)-chrestifoline-C, and improved routes to bismurrayafoline-A, bismurrayafolinol and chrestifoline-D

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00609G, CommunicationHans-Joachim Knolker, Carsten Borger, Arndt W. Schmidt
We describe an efficient synthesis of the methylene-bridged biscarbazole alkaloids bismurrayafoline-A, bismurrayafolinol and chrestifoline B-D using an Ullmann-type coupling at the benzylic position.
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Peptide-catalyzed consecutive 1,6- and 1,4-additions of thiols to [small alpha],[small beta],[gamma],[small delta]-unsaturated aldehydes

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00565A, CommunicationKengo Akagawa, Nobuhiro Nishi, Jun Sen, Kazuaki Kudo
Regio- and enantioselective addition of thiols to [small alpha],[small beta],[gamma],[small delta]-unsaturated aldehydes was performed with a resin-supported peptide catalyst. It was shown that a 1,4-adduct was generated mainly at the initial stage of...
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Recent Development of Two-Photon Fluorescent Probes for Bioimaging

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00431K, Review ArticleDokyoung Kim, Hye Gun Ryu, Kyo Han Ahn
Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed a particular interest in the development of two-photon excitable probes, owing to their advantageous features in...
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Theoretical study on the catalytic mechanism of the retaining [small alpha]-1,2-mannosyltransferase Kre2p/Mnt1p: The impact of different metal ions on catalysis

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00286E, PaperAdela Bobovska, Igor Tvaroska , Juraj Kona
Glycosyltransferases are sugar-processing enzymes that require a specific metal ion cofactor for catalysis. In the presence of other ions the catalysis is often impaired. Here, for the first time, the...
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Novel 3-Arylethynyl-subsititued Thieno[3,4-b]pyrazine Derivatives as a Human Transglutaminase 2 Inhibitors

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00179F, PaperNayeon Kim, Se Hun Kwak, Seon-Hyeong Lee, Vinayak Juvekar, Byung Il Lee, Hee-Chul Ahn, Soo-Youl Kim, Young-Dae Gong
In the process of optimization, we developed a novel core skeleton of thieno[3,4-b]pyrazine via the GK-13 compound. These derivatives were shown to inhibit TGase 2 activity in cancer cells. Some...
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Ring-closing metathesis for the synthesis of a molecular gyrotop

Org. and Biomol. Chem. - 21 min 20 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00470A, CommunicationWataru Setaka, Sayaka Higa, Kentaro Yamaguchi
A molecular gyrotop was synthesized by ring-closing metathesis (RCM) under reflux, indicating that the cage is a thermodynamically controlled product.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Allosteric control of a DNA-hydrolyzing deoxyribozyme with short oligonucleotides and its application in DNA logic gates

Org. and Biomol. Chem. - 21 min 20 sec ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00451E, CommunicationKazuhiro Furukawa, Noriaki Minakawa
We found that the catalytic activity of a DNA-hydrolyzing deoxyribozyme could be allosterically regulated by adding short oligonucleotides, and used this technique to construct DNA logic gates.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Microwave-assisted synthesis of potent PDE7 inhibitors containing a novel thienopyrimidin-4-amine scaffold

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00175C, PaperAna Isabel Sanchez, Ricardo Meneses, Jose Miguel Minguez, Araceli Nunez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Alvarez Builla, Alvaro Cortes-Cabrera, F Gago, Emma Terricabras, Victor Segarra
A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on...
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Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through base mediated one pot inter and intramolecular C-C bond formation strategy

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00432A, PaperRamendra Pratap, Surjeet Singh, Pratik Yadav, Satya Narayan Sahu, Ismail Althagafi, Abhinav Kumar, Brijesh Kumar, Vishnu Ji Ram
A new precursor 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile has been synthesized by reaction of 2-cyanomethylbenzonitrile, carbon disulfide and methyl iodide under basic conditions. Reaction of 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile with various functionalized aryl/heteroaryl methyl ketones or acetone...
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Discrimination of adenine nucleotides and pyrophosphate in water by zinc complex of an anthracene-based cyclophane

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00184B, PaperPing Hu, Shengjun Yang, Guoqiang Feng
Combining metal-anion coordination and [small pi]-[small pi] stacking interactions, zinc complex of a novel anthracene-based cyclophane was designed to recognise adenine nucleoside polyphosphates. This complex was found to show selective fluorescence enhancement...
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Synthesis of [small alpha], [small beta]-unsaturated amides and iminocoumarins from N,N-disulfonyl ynamides with aldehydes via ketenimines intermediate

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00513A, PaperLian Yu, Jian Cao
A novel synthesis of [small alpha], [small beta]-unsaturated amides from N,N-disulfonyl ynamides with aldehydes was developed. By utilization of salicylaldehydes, a variety of substituted iminocoumarins were prepared.
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Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00670D, PaperJiaxing Hu, Zhihong Deng, xueqiong Zhang, Fanglin Zhang, hua zheng
A convenient one-pot reaction was conducted by mixing bromoacetophenone, functional [small alpha], [small beta]-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting...
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Construction of Rotacatenanes Using Rotaxane and Catenane Frameworks

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00602J, PaperJun Yin, Wen Xue, Ziyong Li, Guoxing Liu, Xiaoqiang Chen, Tingting Li, Shenghua Liu
The construction of novel mechanically interlocked structures has become a fashion due to the requirements of topology and their potential application in molecular machines and devices. Rotaxane and catenane as...
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Interaction of Amphiphilic [small alpha]-Helical Cell-Penetrating Peptides with Heparan Sulfate

Org. and Biomol. Chem. - 21 min 20 sec ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00673A, PaperJi Yang, Hiroshi Tsutsumi, Tadaomi Furuta, Minoru Sakurai, Hisakazu Mihara
Cell-penetrating peptides (CPPs) are able to be taken up by cells and can deliver macromolecular cargos. However, the mechanism of this internalization is not yet fully understood. Recent theories suggest...
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