Royal Society of Chemistry

An Easy Access to [small alpha]-Aryl Substituted [gamma]-Ketophosphonates: Lewis Acid Mediated Reactions of 1,3-diketones with [small alpha]-hydroxyphosphonates and Tandem Regioselective C-C Bond Cleavage

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01091D, PaperGangaram Pallikonda, manab chakravarty, Manoj Kumar Sahoo
A range of [small alpha]-aryl substituted [gamma]-ketophosphonates is synthesised by Lewis acid mediated reactions of 1,3-diketones and easily accessible, inexpensive benzylic [small alpha]-hydroxyphosphonates in an operationally-simple method under solvent-free conditions without exclusion...
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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

Org. and Biomol. Chem. - 5 hours 8 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
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Design and Synthesis of a Macrosphelide A-Biotin Chimera

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01028K, PaperYoung-Ger Suh, Hwayoung Yun, Jaehoon Sim, Hongchan An, Jeeyeon Lee, Hun Seok Lee, Young Kee Shin, Seung-Mann Paek
The rational design and synthesis of a biochemical probe of natural (+)-macrosphelide A, a potent cell-cell adhesion inhibitor, was completed to aid in the identification of its biological target. The...
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Large dipole moment to promote gelation for 4-nitrophenylacrylonitrile derivatives with gelation-induced emission enhancement property

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00768A, Paperpeng chong Xue, Boqi Yao, Yuan Zhang, Peng Chen, kechang li, Baijun Liu, Ran Lu, Qiux xu
A series of 4-nitrophenylacrylonitrile and phenylacrylonitrile derivatives consisting of carbazole moiety was synthesized. Some of these derivatives with longer alkyl chains and nitro group could gelatinize some organic solvents, such...
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Effect of Conformational Rigidity on the Stereoselectivity of Nucleophilic Additions to Five-membered Ring Bicyclic Oxocarbenium Ion Intermediates

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01251H, PaperOlga Lavinda, Vi Tran, Keith Woerpel
Nucleophilic substitution reactions of five-membered ring acetals bearing fused rings reveal that subtle changes in structure of the fused ring can exert dramatic influences on selectivity. If the fused ring...
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Expedient Synthesis of [small alpha]-S-(1[rightward arrow]6)-Linked Pentaglucosyl Thiol

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01094A, PaperHuali Wang, Xiangming Zhu
An [small alpha]-S-(1[rightward arrow]6)-linked pentaglucosyl thiol has been synthesized in a convenient and stereoselective way. Key steps of the synthesis involved thioglycosylation of 6-iodinated sugars with [small alpha]-glycosyl thiols under phase transfer conditions....
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Recent Advances in Catalytic C-N bond Formation: A Comparison of Cascade Hydroaminomethylation and Reductive Amination Reactions with the Corresponding Hydroamidomethylation and Reductive Amidation Reactions

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00620H, Review Articlesaeed raoufmoghaddam
The design and catalytic implementation of tandem reactions to selectively create nitrogen-containing products under mild conditions has encountered numerous challenges in synthetic chemistry. Several known classes of the homogeneously catalyzed...
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Total Synthesis of Putative Montamine and a Proposed Structural Reassignment

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01304B, PaperJonathan Sperry, Elizabeth Colby Davie, Lachlan Blair
The natural product montamine was originally assigned as a homodimer of moschamine linked by a N-Nʹ bond at the serotonin side-chain. A total synthesis of the reported structure has shown...
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E Nielsen
We report the first PNA self-replicating system based on template directed cross-catalytic ligation, a process analogous to biological replication. Using two decameric template PNAs and four pentameric precursor PNAs, all...
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Ratiometric fluorescent chemosensor based on Tyrosine derivatives for monitoring mercury ions in aqueous solutions

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01044B, PaperPoonaboina Thirupathi, Ponnaboina Saritha, Keun-Hyeung Lee
Ratiometric fluorescent chemosensors, 1 and 2 were synthesized based on Tyrosine amino acid derivatives with a pyrene fluorophore. 1 and 2 displayed high selectivity for Hg(II) ions among 13 metal...
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A General catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00846D, PaperHui Peng, Ya-Qin Chen, Shu-Lan Mao, Yunxiao Pi, You Chen, Zeyu Lian, Tong Meng, Shenghua Liu, Guang-Ao Yu
We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl) dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki-Miyaura and Sonogashira coupling reactions in water (and biphasic water-organic solvent mixtures) to prepare a...
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Highly Efficient Synthesis of A Tristable Molecular Shuttle and Its Controlled Motion Under Chemical Stimuli

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01283F, PaperZheng Meng, Chuan-Feng Chen
According to the threading-followed-by-stoppering approach, a tristable molecular shuttle could be efficiently synthesized in 76% yield by using K+ ions template and bulky isocyanate stopper. This high yield was reasoned...
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Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

Org. and Biomol. Chem. - 5 hours 8 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01115E, PaperJong-Hwan Jeon, Kazuo Tanaka, Yoshiki Chujo
The light-driven artificial enzymes were constructed to realize unnatural reactions concerning biomolecules. The guanosine triphosphate-selective oxidation was accomplished using the network polymers in which the molecular recognition via hydrogen bonds can be enhanced.
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Iridium(I) hydroxides in catalysis: rearrangement of allylic alcohols to ketones

Org. and Biomol. Chem. - 5 hours 8 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01428F, PaperDavid J. Nelson, Jose A. Fernandez-Salas, Byron J. Truscott, Steven P. Nolan
The iridium(I) hydroxide complex [Ir(OH)(COD)(IiPr)] has been shown to be a competent catalyst for the rearrangement of allylic alcohols to ketones.
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Palladium-Catalyzed Carbonylative Addition of Aryl Bromides to Arylalkynes: A Simple and Efficient Method for Chalcone Synthesis

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01263A, PaperSheng Zhang, Liangguang Wang, Xiujuan Feng, Ming Bao
Palladium-catalyzed carbonylative addition of aryl bromides to terminal arylalkynes was carried out to produce chalcones in satisfactory to excellent yields. The unprecedented carbonylation reaction proceeded smoothly under mild conditions in...
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First Stereoselective Total Synthesis of Neosemburin and Isoneosemburin

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01239A, PaperRamu Sridhar Perali, Madhusudhan Reddy Gadi
The Claisen rearrangement of sugar derived allyl vinyl ether, Wittig olefination and intramolecular acetalization reactions were used as key steps in the first stereoselective total synthesis of neosemburin and isoneosemburin...
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Monitoring penetratin interactions with lipid membranes and cell internalization using a new hydration-sensitive fluorescent probe

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01242A, PaperOleksandr M. Zamotaiev, Viktoriia Y. Postupalenko, Volodymyr V. Shvadchak, Vasyl Pivovarenko, Andrey S Klymchenko, Yves Mely
A new fluorescent label N-[4'-(dimethylamino)-3-hydroxyflavone-7-yl]-N-methyl-[small beta]-alanine (7AF) was synthesized. Due to two electron donor groups at the opposite ends of the chromophore, an excited state intramolecular proton transfer (ESIPT) resulting in...
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Monopyrrolotetrathiafulvalene-succinamide conjugates and their TCNQ charge transfer complex based supramolecular gels with multiple stimulus responsiveness

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01397B, PaperYucun Liu, ningjuan zheng, Tie Chen, Long Yi Jin, Bingzhu Yin
A series of monopyrrolotetrathiafulvalene-succinamide conjugates and their 7,7,8,8-tetracyano-p-quinodimethane (TCNQ) charge transfer (CT) complexes have been synthesized and investigated as new low-molecular mass organogelators. The gelation capability of these conjugates is...
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Stereoselective Synthesis of O-Tosyl Azabicyclic Derivatives via Aza Prins Reaction of Endocyclic N-Acyliminium Ions: Application to the Total Synthesis of (+/-)-epi-Indolizidine 167B and 209D

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01130A, PaperAnil Saikia, Kiran Indukuri, Jagadish Das
A diastereoselective protocol has been established for the synthesis of 4-O-tosyl piperidine containing hexahydroindolizin-3(2H)-one, hexahydro-1H-quinolizin-4(6H)-one and 1,3,4,10b-tetrahydropyrido[2,1-a]isoindol-6(2H)-one derivatives via the aza-Prins cyclization reaction of cyclic N-acyliminium ions mediated by p-toluene...
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A one-pot synthetic strategy for construction of dibenzodiazepine skeleton via transition metal-free process

Org. and Biomol. Chem. - 5 hours 8 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00871E, PaperShuai Fang, Xiaoyi Niu, Zeyuan Zhang, Yan Sun, Xiaomeng Si, Cuicui Shan, Lei Wei, Aiqing Xu, Lei Feng, chen ma
A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed. Fluoro-, bromo- and nitro-substituted aryl aldehydes were applied to this reaction efficiently.
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