Royal Society of Chemistry

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01478F, PaperMarina Fosso Yatchang, Harry LeVine, III, Keith D Green, Oleg Tsodikov, Sylvie Garneau-Tsodikova
As the number of individuals affected with Alzheimer's disease (AD) increases and the availability of drugs for AD treatment remains limited, the need to develop effective therapeutics for AD becomes...
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Convenient synthesis and application of versatile nucleic acid lipid membrane anchors in the assembly and fusion of liposomes

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01207D, PaperStefan Vogel, Philipp Max Loffler, Oliver Ries
Hydrophobic moieties like lipid membrane anchors are highly demanded modifications for nucleic acid oligomers. Membrane-anchor modified oligonucleotides are applicable in biomedicine leading to new delivery strategies as well as in...
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Copper-catalysed azide-alkyne cycloadditions (CuAAC): an update

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01457C, Review ArticlePedro J. Perez, Estela Haldon, M. Carmen Nicasio
The reaction of organic azides and alkynes catalysed by copper species represents the prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed azide-alkyne cycloaddition), discovered in 2002, has been...
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Macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01400J, PaperMohamed A. Ibrahim, Siva S Panda, Alexander Oliferenko, Polina V Oliferenko, AS Girgis, Mohamed Elagawany, F Z Kucukbay, Chandramukhi S Panda, Girinath G. Pillai, Ahmed Samir, Kaido Tamm, Charles Dennis Hall, Alan R Katritzky
Novel, cyclic peptidomimetics were synthesized by facile acylation reactions using benzotriazole chemistry. Microbiological testing of the synthesized compounds revealed an exceptionally high activity against Candida albicans with a minimum inhibitory...
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A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01484K, CommunicationDipak Prajapati, Yuvaraj Dommaraju, Shruti Bora
A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished by a three-component reaction involving sulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil. The method...
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The interface makes a difference: Lanthanide ion coated vesicles hydrolyze phosphodiesters

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01265A, PaperBurkhard Koenig, Michal Poznik, Uday Maitra
Lanthanide ions are strong Lewis acids. The complexation to a variety of ligands can further enhance the Lewis acidity allowing the hydrolysis of phosphoesters and even DNA. We show that...
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Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces Isolate

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01269D, PaperMostafa E Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, mervyn bibb, Kwaku Kyeremehe, Pieter C. Dorrestein, Kui Hong, Marcel Jaspars, Hai Deng
Linaridins are rare linear ribosomally-synthesized and post-translationally modified peptides (RiPPs) and only two, cypemycin and SBR-1832, in this family have been identified so far. Legonaridin 1 has been discovered as...
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Origins of Observed Reactivity and Specificity in the Addition of B2Cl4 and Analogues to Unsaturated Compounds

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01280E, PaperJ M Brown, Carles Bo, Elena Fernandez, cristina pubill-ulldemolins
In 1954 Schlesinger and co-workers observed the direct reaction of diboron tetrachloride with simple organic compounds under mild conditions, the 1,2 addition product being formed with either ethylene or acetylene....
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Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Org. and Biomol. Chem. - 1 hour 58 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00898K, PaperP. Srivastava, R. Abou El Asrar, C. Knies, M. Abramov, M. Froeyen, J. Rozenski, H. Rosemeyer, P. Herdewijn
The search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking.
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Strategy of total synthesis based on the use of Rh-catalyzed stereoselective 1,4-addition.

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01402F, Review ArticleMickael Jean, Bruna Casanova, Simone Gnoatto, Pierre van de Weghe
In 1998, Hayashi and Miyaura reported the first asymmetric conjugate addition of aryl- and alkenyl- boronic acids to [small alpha],[small beta]-unsaturated ketones using chiral rhodium complexes as catalysts. During the last decade,...
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Total Synthesis of the Natural Product EBC-329

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01276G, CommunicationRaju Thombal, Vrushali H Jadhav
The first total synthesis of anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo [3.1.0] hexane-2,4-dione (7). An efficient and general approach has been reported...
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Application of RDCs Enhanced NMR Spectroscopy in Structural Analysis of Thiacalix[4]arene Derivatives

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01424G, PaperLukas Vrzal, Marketa Kratochvilova-Simanova, Tomas Landovsky, Katerina Polivkova, Jan Budka, Hana Dvorakova, Pavel Lhotak
Thiacalix[4]arene spirodienone was rearranged into the corresponding phenoxathiin-based macrocycle. Alkylation of this inherently chiral system to achieve its immobilization led to a mixture of only two (out of four theoretically...
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Array-based sensing of purine derivatives with fluorescent dyes

Org. and Biomol. Chem. - 1 hour 58 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01201E, PaperZiya Kostereli, Kay Severin
A sensor array based on polysulfonated fluorescent dyes can be used to differentiate purine and its derivatives with good precision.
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Direct synthesis of methyl phosphoramidates in carbohydrates

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01017A, PaperVijay Dhurandhare, Girija Prasad Mishra, Sarah Lam, Cheng-Chung Wang
A direct installation of methyl phosphoramidate group by using methyl benzylphosphoramidochloridate into carbohydrates and amino acid is described. This one-step synthesis is efficient for both primary and secondary alcohols and...
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One-Pot Synthesis of GABA Amides via the Nucleophilic Addition of Amines to 3,3-Disubstituted Cyclopropenes

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01462J, CommunicationVladimir A Maslivetc, Marina Rubina, Michael Rubin
A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carbox¬amides, followed by ring-opening of the...
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Experimental design, modeling and optimization of polyplex formation between DNA oligonucleotide and branched polyethylenimine

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01189B, PaperAlexandru Rotaru, Lilia Clima, Elena Laura Ursu, Corneliu Cojocaru, Mihail Barboiu, Mariana Pinteala
The complexes formed by DNA and polycations have received a great attention owing to their potential application in gene therapy. In this study, the binding efficiency between double-stranded oligonucleotide (dsDNA)...
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Cu-Mediated Direct Regiose-lective C-2 Chlorination of Indoles

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01228G, CommunicationJing Zhao, Xiuzhi Cheng, Jun Le, Wei Yang, Fengtian Xue, Xuan Zhang, Chao Jiang
Cu-mediated C-2 chlorination of indoles were accomplished with copper(II) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of...
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A Fluorescent Turn-on H2S-responsive Probe: Design, Synthesis and Application

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01305D, PaperJun Yin, Yufeng Zhang, Haiyan Chen, Dan Chen, Di Wu, Xiaoqiang Chen, Shenghua Liu
Hydrogen sulfide (H2S) is considered as the third signaling molecule in vivo and it plays an important role in various physiological processes and pathological processes in vivo, such as vasodilation,...
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Enantioselective Cascade Double Michael Addition of 3-Nitro-2H-Chromenes and Acyclic Enones: Efficient Synthesis of Functionalized Tricyclic Chroman Derivatives

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01211B, PaperJun-Hua Li, Da-Ming Du
An efficient protocol for the asymmetric construction of enantiomerically enriched tetrahydro-6H-benzo[c]chromenes, tetrahydro-6H-benzo[c]thiochromene or hexahydrophenanthrene and their derivatives have been developed. The corresponding products were obtained by the cascade double Michael...
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Recent synthetic additions to the visible light photoredox catalysis toolbox

Org. and Biomol. Chem. - 1 hour 58 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01349F, Review ArticleG B Hammond, Ricardo Almir Angnes, Zhou Li, Carlos Roque Correia
The boom in visible light photoredox catalysis (VLPC) research has demonstrated that this novel synthetic approach is here to stay. VLPC enables reactive radical intermediates catalytically generated at ambient temperature,...
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