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Exceptional Hydrophobicity of a Large-Pore Metal–Organic Zeolite

J. Am. Chem. Soc. - 26 May, 2015 - 19:37

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Journal of the American Chemical SocietyDOI: 10.1021/jacs.5b03727

Catalyst-Free Direct Decarboxylative Coupling of [small alpha]-Keto Acids with Thiols: A Facile Access to Thioesters

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00769K, PaperKelu Yan, Daoshan Yang, Wei Wei, Jing Zhao, Yuanyuan Shuai, Laijin Tian, Hua Wang
A novel, efficient, and catalyst-free strategy has been initially developed for the construction of thioesters via the direct radical oxidative decarboxylation of [small alpha]-keto acids with thiols, and the corresponding target...
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Construction of Photoswitchable Rotaxanes and Catenanes Containing Dithienylethene Fragments

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00864F, PaperJun Yin, Ziyong Li, xie han, Haiyan Chen, Di Wu, Fang Hu, Shenghua Liu
Mechanically interlocked structures such as rotaxane and catenane provide a novel backbone for constructing the functional materials with a unique structural characterization. In this work, we design and synthesize a...
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Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00714C, PaperShohei Takase, Yusuke Saga, Nozomi Kurihara, Shingo Naraki, Kenta Kuze, Genki Nakata, Takeshi Araki, Tetsuo Kushiro
Oxidosqualene cyclases (OSCs) catalyze the cyclization of an acyclic substrate into various polycyclic triterpenes through a series of cation-[small pi] cyclization and 1,2-rearrangement processes. The mechanisms by which OSCs control the...
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Truce-Smiles rearrangement of substituted phenyl ethers

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00812C, PaperJoel R. Kosowan, Zemane W'Giorgis, Ravneet Grewal, Tabitha E. Wood
This study of the Truce-Smiles rearrangement has revealed interesting tandem reactions, unprecedented systematic substituent effects, and new mechanistic insight.
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Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00928F, CommunicationAmandeep Kaur, Kurt W. L. Brigden, Timothy F. Cashman, Stuart T. Fraser, Elizabeth J. New
NpFR2 is a fluorescent sensor that can reversibly measure changes in the mitochondrial redox environment.
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Cyanine Fluorophore for Cellular Protection Against ROS in Stimulated Macrophages and Two-Photon ROS Detection

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00643K, PaperMiu Shan Chan, Di Xu, Lei Guo, Dick Yan Tam, Ling Sum Liu, Man Shing Wong, Pik Kwan Lo
We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for detection of three biologically important ROS namely, .OH, O2- and OCl-...
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Gold and silver catalysis: from organic transformation to bioconjugation

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00407A, Review ArticleVanessa Kar-Yan Lo, Anna On-Yee Chan, Chi-Ming Che
A summary of gold (including AuNPs, Au(I) and Au(III) complexes) and silver(I) catalysis and their application in bioconjugation reactions.
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Synthesis of Tetraarylpyridines by Chemo-Selective Suzuki-Miyaura Reactions of 3,5-Dibromo-2,6-dichloropyridine

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00866B, PaperSebastian Reimann, Silvio Parpart, Peter Ehlers, Muhammad Sharif, Anke Spannenberg, Peter Langer
Chemoselective Suzuki-Miyaura reactions on 3,5-dibromo-2,6-dichloropyridine were studied. The optimized reaction conditions allow for the facile access of 3-aryl- and 3,5-diarylpyridines in good yields. Suzuki-Miyaura reactions of the selectively synthesized 2,6-dichloro-3,5-diarylpyridines...
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The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-Hepatic Fibrosis agents

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00710K, Paperxin zhou, xue wu, juan xiao, chunmei jin, Zhixue Liu, Shujing Guo, xiaochuan zhang
1-benzyl-3-(substituted aryl)-5-methylfuro[3, 2-c]pyrazoles (YC-1) is a well-known synthetic compound with various satisfactory pharmacological activities, such as the activation of soluble gualylate cyclase (sGC) and the inhibition of hypoxia-induced factor-1 (HIF-1)....
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Copper Catalysed Direct Amidation of Methyl Groups with N-H Bonds

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00685F, PaperYao Huang, Tieqiao Chen, Qiang Li, Yongbo Zhou, S.-F. Yin
An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including...
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An Update on New Methods to Synthesize Cyclotetrapeptides

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00880H, PerspectiveMargaret A Brimble, Luis M De Leon Rodriguez, Andreas Weidkamp
Cyclotetrapeptides are important bioactive lead drug molecules that display a wide spectrum of pharmacological activities. However, the synthesis of cyclotetrapeptides from their linear precursors is challenging due to the highly...
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Synthesis of carbazoloquinone natural products 'on-water'

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00852B, PaperChristopher McErlean, Philip Norcott
The total synthesis of a number of carbazolo-1,4-quinone natural products using on-water chemistry is described. A recently developed domino 'in-water, on-water' process is employed to rapidly and efficiently generate koniginequinone...
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Copper-Catalyzed Efficient Direct Amidation of 2-Methylquinolines with Amines

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00915D, CommunicationGuo-Jun Deng, Hao Xie, Yunfeng Liao, Shuqing Chen, Ya Chen
A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an effieient approach for the synthesis of biologically important aromatic amides from readily available coupling partners...
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Selective photoregulation of the activity of glycogen synthase and glycogen phosphorylase, two key enzymes in glycogen metabolism

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00796H, PaperJoan C Ferrer, Mireia Diaz-Lobo, Jaume Garcia-Amoros, Ignacio Fita, Dolores Velasco, Joan J Guinovart
Glycogen is a polymer of [small alpha]-1,4- and [small alpha]-1,6-linked glucose units that provides a readily available source of energy in living organisms. Glycogen synthase (GS) and glycogen phosphorylase (GP) are the...
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Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as flexible linker

Org. and Biomol. Chem. - 26 May, 2015 - 14:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00430F, PaperXiaoyan Pan, Jinyun Dong, Yaling Shi, Ruili Shao, Fen Wei, Jinfeng Wang, Jie Zhang
Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and characterized as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five compounds 8d, 8h, 8l, 10m...
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CuX2-mediated oxybromination/aminochlorination of unsaturated amides: synthesis of iminolactones and lactams

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00520E, CommunicationZhi-Qiang Zhang, Feng Liu
A CuX2-mediated halocyclization of [gamma],[small delta]-unsaturated amides for the synthesis of functionalized iminolactones and lactams respectively is described.
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Glycosmisines A and B: isolation of two new carbazole-indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00695C, PaperYu Chen, Chu Tang, Yi Wu, Shasha Mo, Sha Wang, Guangzhong Yang, Zhinan Mei
Two unique carbazole-indole-type dimeric alkaloids, glycosmisines A (1) and B (2), have been isolated from the stems of Glycosmis pentaphylla and their structures are elucidated by 1D and 2D NMR analyses).
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4-(Dimethylamino)pyridine-catalysed iodolactonisation of [gamma],[small delta]-unsaturated carboxylic acids

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00806A, PaperChuisong Meng, Zhihui Liu, Yuxiu Liu, Qingmin Wang
4-(Dimethylamino)pyridine functioned as an excellent catalyst for iodolactonization reactions of [gamma],[small delta]-unsaturated carboxylic acids, affording [gamma]-lactones, [small delta]-lactones, or both.
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Nickel-catalyzed synthesis of diarylsulfides and sulfones via C-H bond functionalization of arylamides

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00149H, PaperVutukuri Prakash Reddy, Renhua Qiu, Takanori Iwasaki, Nobuaki Kambe
The sulfenylation and sulfonylation of (sp2)C-H bonds of benzamides were achieved with the aid of a bidentate directing group.
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