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Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00199D, PaperSiyoong Seo, Kazumitsu Onizuka, Chieko Nishioka, Eiki Takahashi, Satoshi Tsuneda, Hiroshi Abe, Yoshihiro Ito
The representative DNA-labeling agent 5-ethynyl-2'-deoxyuridine (EdU) was chemically modified to improve its function. Chemical monophosphorylation was expected to enhance the efficiency of the substrate in DNA polymerization by circumventing the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalytic Enantioselective Michael Addition of Cyclic Hemiacetals to Nitroolefins: A Facile Access to Chiral Substituted 5- and 6-Membered Cyclic Ethers

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00202H, PaperShilei Zhang, Pengfei Qian, Shaohua Chen, Yanwei Hu, Wei Wang, jiyang Yang, Ping Wu, Wei Zhang, Yadong Zhu
An efficient aminocatalytic enantioselective Michael addition of readily available cyclic hemiacetals to nitroolefins has been developed. The strategy serves as a powerful approach to synthetically valued chiral 3-substituted tetrahydrofurans (THFs)...
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Tandem Reactions of Substituted 3-Sulfolenes with Bis-Vinyl Ketones Leading to Highly Functionalized Bicyclic and Tricyclic Frameworks

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00387C, PaperMichael G Brant, Jordan Friedmann, Connor G Bohlken, Allen Grayson Oliver, Jeremy E Wulff
The base-promoted reaction of 3-sulfolene with bis-vinyl ketones was shown in earlier work to proceed through a -1,2 addition/anionic oxy-Cope cascade; a subsequent treatment with base induced a second -1,2...
The content of this RSS Feed (c) The Royal Society of Chemistry

Room Temperature N-Arylation of Amino Acids and Peptides Using Copper(I) and [small beta]-diketone

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00288E, CommunicationR Jain, Krishna Kumar Sharma, Swagat Sharma, Anurag Kudwal
A mild and efficient method for the N-arylation of zwitterionic amino acids, amino acid esters and peptides is described. The procedure provides the first room temperature synthesis of N-arylated amino...
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Synthesis of bifunctional molecules containing [12]aneN3 and coumarin moieties as effective DNA condensation agents and new non-viral gene vectors

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02676D, PaperPan Yue, Ying Zhang, Zhi-Fo Guo, C. Aocheng, Zhong-Lin Lu, Yong-Gong Zhai
A series of bifunctional molecules with different combinations of macrocyclic polyamine [12]aneN3 and coumarin moietie, 4a/b and 5a/b, were synthesized by the two-step copper(I)-mediated alkyne-azide click reactions between 1,3,5-tris(azidomethy)benzene and...
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Design, Synthesis and Biological Evaluation of Novel Peptide MC2 Analogues from Momordica charantia as Potential Anti-diabetic Agents

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00333D, PaperBaowei Yang, Xue Li, Chenyu Zhang, Sijia Yan, Wei Wei, Xuekun Wang, Xin Deng, Hai Qian, Haiyan Lin, Wenlong Huang
Three series of Momordica charantia (MC)2 analogues were designed, synthesized and evaluated for their anti-hyperglycaemic effects. Alanine scanning focusing on the peptide MC2 indicated the importance of the residues proline...
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Mitsunobu mischief: neighbor-directed histidine N([small tau])-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles

Org. and Biomol. Chem. - 6 March, 2015 - 17:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00171D, PaperWen-Jian Qian, Terrence R. Burke
Selective on-resin histidine N([small tau])-alkylation under Mitsunobu conditions is achieved by the coordinated participation of a proximal acidic residue.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Synthesis of chitin and chitosan stereoisomers by thermostable alpha-glucan phosphorylase-catalyzed enzymatic polymerization of alpha-D-glucosamine 1-phosphate

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00167F, PaperJun-ichi Kadokawa, Riko Shimohigoshi, Kento Yamashita, Kazuya Yamamoto
The relationship between two aminopolysaccharide stereoisomers, namely alpha-(1,4)- and beta-(1,4)-linked (N-acetyl)-D-glucosamine polymers, is of significant interest within the field of polysaccharide science, as they correspond to amino analogs of the...
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Organocatalytic asymmetric Michael addition of 3-substituted oxindoles to [small alpha],[small beta]-unsaturated acyl phosphonates for the synthesis of 3,3'-disubstituted oxindoles with chiral squaramides

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00317B, CommunicationLin Chen, Yong You, Ming-Liang Zhang, Jian-Qiang Zhao, Jian Zuo, Xiao-Mei Zhang, Weicheng Yuan, Xiao-Ying Xu
A highly enantioselective Michael addition of 3-monosubstituted oxindoles to [small alpha],[small beta]-unsaturated acyl phosphonates with chiral squaramides as catalysts was investigated for the first time. A wide range of 3,3'-disubstituted oxindole adducts...
The content of this RSS Feed (c) The Royal Society of Chemistry

PtI2-Catalyzed Cyclization of 3-Acyloxy-1,5-enynes with the Elimination of HOAc and a benzyl Shift: Synthesis of Unsymmetrical m-Terphenyls

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02336F, Paperlingyan liu, Jing Li, xiufang xu, Kaimeng Huang, Hongkai Wang, Junying Wang, Xiaona Ke, Chenchen Zhou
A novel cyclization of 3-acyloxy-1,5-enynes was developed in the presence of PtI2 for the synthesis of substituted unsymmetrical m-terphenyls in good to excellent yields. Two unique steps were involved in...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of novel tryptamine-based macrocycles using a Ugi 4-CR/microwave assisted click-cycloaddition reaction protocol

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00067J, CommunicationLuis D. Miranda, Lizbeth Chavez-Acevedo
A practical synthesis of novel tryptamine-based macrocycles using a Ugi 4-CR/click-cycloaddition sequential reaction protocol is descrived. The main features of the macrocyclic scaffolds are a peptoid moiety, a 1,3-substituted indole...
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-Catalyzed Oxidative C-H/C-H Cross-Coupling of 1-Substituted 1,2,3-Triazoles with Furans and Thiophenes

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00102A, PaperXin Yu, Wei Liu, Suping Shi, Chunxiang Kuang, Zhendong Huang
Palladium-catalyzed heteroarylation of 1-substituted 1,2,3-triazoles with furans and thiophens has been developed, in the presence of pyridine and Ag2CO3. The procedure is suitable for the regioselective preparation of 1,5-disubstituted 1,2,3-triazoles...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chirality Extension of Oxazine Building Block En Route to Total Syntheses of (+)-Hyacinthacine A2 and Sphingofungin B

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00251F, PaperSeok-Hwi Park, Xiangdan Jin, Jong-Cheol Kang, Changyoung Jung, Seong-Soo Kim, Sung-Soo Kim, Kee-Young Lee, Won Hun Ham
Concise and stereocontrolled syntheses of (+)-hyacinthacine A2 and sphingofungin B were achieved via a diastereomerically enriched oxazine intermediate. The key strategies include palladium(0)-catalyzed intramolecular oxazine formation and diastereoselective nucleophilic addition...
The content of this RSS Feed (c) The Royal Society of Chemistry

Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00318K, PaperElena Pazos, Cecilia Portela, Cristina Penas, M. Eugenio Vazquez, Jose Luis Mascarenas
We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as...
The content of this RSS Feed (c) The Royal Society of Chemistry

Near-infrared emission of dibenzoxanthenium and its application in the design of nitric oxide probes

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00042D, PaperWu Liu, Chen Fan, Ru Sun, Yu-Jie Xu, Jian-Feng Ge
Two dibenzoxanthenium derivatives bearing a 3,4-diaminophenyl group, compounds 1a and 1b, have been prepared and evaluated as near-infrared probes for the detection of nitric oxide. Compound 1a gave a 3-fold...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 2,4-diarylsubstituted-pyridines through Ru-catalyzed four component reaction

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00162E, CommunicationGuo-Jun Deng, Yang Bai, Lichang Tang, Huawen Huang
A ruthenium-catalyzed one-pot synthesis of 2,4-diarylsubstituted pyridines from acetophenones, ammonium acetate and DMF under oxygen atmosphere is described. The carbon atom situated at C6 of the pyridine ring comes from...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chemical Synthesis of Outer Core Oligosaccharide of Escherichia coli R3 and Immunological Evaluation

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00177C, PaperWenjing Shang, Zhongying Xiao, Zaikuan Yu, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang, Tiehai Li
Lipopolysaccharides (LPS), major virulence determinants in Gram?negative bacteria, are responsible for many pathophysiological responses and can elicit strong immune responses. In order to better understand the role of LPS in...
The content of this RSS Feed (c) The Royal Society of Chemistry

Facile synthesis of spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines and their fungicidal activity

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00258C, PaperChangjiang Yang, Juanjuan Li, Rong Zhou, Xiangyu Chen, Yunpeng Gao, Zhengjie He
Novel spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines have been synthesized in good to excellent yields via the annulation reactions of the corresponding 3-alkylideneoxindoles and 3-alkylidenebenzofuranones with Huisgen zwitterions. The preliminary bioassay has demonstrated...
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An Efficient Access to Enantiopure 1,3-disubstituted Isoindolines from Selective Catalytic Fragmentation of Original Desymmetrized Rigid Overbred Template

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00229J, PaperGanesh Pandey, Rajesh Varkhedkar, Divya Tiwari
An efficient and scalable synthesis of various enantiopure 1,3- disubstituted isoindolines are reported. The base catalyzed nucleophilic fragmentation of a rigid overbred template is established with various substrates to afford...
The content of this RSS Feed (c) The Royal Society of Chemistry

Concise Synthetic Approach to Brazilin via Pd-Catalyzed Allylic Arylation

Org. and Biomol. Chem. - 6 March, 2015 - 17:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00216H, PaperYoungeun Jung, Ikyon Kim
A short synthetic route to the trimethyl ether of brazilin was developed in 6 steps from 7-methoxychromene with 78% overall yield. Regioselective installation of a formyl group onto 7-methoxychromene followed...
The content of this RSS Feed (c) The Royal Society of Chemistry

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