PAMAM as gene carrier to enhance transfer efficiency.

PAMAM as gene carrier to enhance transfer efficiency.
PAMAM with DNA can form stable compound, the complex entered by cellular endocytosis into the cell, DNA fight against lysosomal degradation, PAMAM internal multistage amine has good buffer capacity to protect the DNA, and released DNA under the acid conditions to achieve the purpose of transfer. Amidization is easy, by controlling the amount of octadecadienoic acid chloride, grafting it with dendrimer to form the external hydrophobic and internal hydrophilic dendrimer, it can well combinate with DNA in gene transfer process, thereby improving the efficiency of gene transfer. Professional Manufacturer for low cost dendritic polymers.-Weihai CY Dendrimer Technology Co. Ltd. forwards from "Preparation and Transfer Efficiency of Modified PAMAM Dendrimer Gene Delivery" Liu Junan, Wei Xiaolei, Jiang Hong, Zhong Wenzhong, College of Science,Huazhong Agricultural University, Wuhan 430070,China;Hubei Nanxing Chemical General Facory,Zhijiang 43200,China.

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