PAMAM has good application in the drugs carrier field of anti-tumor.
5-fluorouracil (5FU) has significant anti-tumor activity, but it has a higher toxic side effects. PAMAM and 5-fluorouracil combine together to form dendrimer-5FU conjugates and release toxicity of 5FU. Thus better for the the anti-tumor drugs carrier. The fluorinated dendrimer is soluble in supercritical CO2, strongly hydrophilic compounds can be extracted from the water to the liquid CO2. Thus in industry, the liquid CO2 replaces harmful organic solvents. Weihai CY Dendrimer Technology Co. Ltd forwards from “Dendrimers: properties and applications”, Barbara Klajnert, and Maria Bryszewska, Department of s General Biophysics, University of to £ ódŸ the £ ódŸ, Poland Vol 48 No. 1/2001 199-208 Quarterly.